Darwin J. Prockop, M.D., Ph.D.
Professor
Director, Institute for Regenerative Medicine
Department of Molecular and Cellular Medicine
5701 Airport Road, Module C
Temple,
TX 76502
Phone: 254-771-6810
Fax: 254-771-6839
Email: prockop@medicine.tamhsc.edu
Lab Webpage: http://medicine.tamhsc.edu/irm
Education and Post-Graduate Training
Research Interests
Selected Publications
Gregory, C. A., Prockop, D. J., and Spees, J. L. (2005) "Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation." Experimental Cell Research. 306: 330-335.
Gunn, W.G., Conley, A., Deininger, L., Olson, S.D., Prockop, D. J., and Gregory, C.A. (2005) "A Crosstalk between Myeloma Cells and Marrow Stromal Cells Stimulates Production of DKK1 and IL-6: A Potential Role in the Development of Lytic Bone Disease and Tumor Progression in Multiple Myeloma." Stem Cells. 24: 986-991.
Munoz, J. R., Stoutenger, B.R., Robinson, A.P., Spees, J.L., and Prockop, D.J. (2005) "Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice." Proceedings of the National Academy of Sciences. 102: 18171-18176.
Lee, R.H., Hsu, S. C., Munoz, J., Jung, J.S., Lee, N.R., Pochampally, R., and Prockop, D. J. (2006) "A subset of human rapidly-self renewing marrow cells (MSCs) preferentially engraft in mice." Blood. 107: 2153-2161.
Lee, R.H., Seo, M.J., Reger, R.L., Spees, J.L., Pulin, A.A., Olson S.D., and Prockop, D.J. (2006) "Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and perhaps renal glomeruli in diabetic NOD/scid mice." Proceedings of the National Academy of Sciences USA. 103: 17438-17443.
Iso, Y., Spees, J.L., Serrano, C., Bakondi B., Pochampally R., Song, Y.-H., Sobel B.E., Delafontaine, P., and Prockop, D.J. (2007) "Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment". Biochemical and Biophysical Research Communications. 354: 700-706.
Prockop, D. J. (2007) "Stemness” does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs)." Clinical Pharmacology and Therapeutics. 82: 241-243..
Ohtaki, H., Ylostalo, J., Foraker, J. E., Robinson, A. P., Reger R. L., Shioda S., and Prockop, D.J. (2008) "Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory immune responses." Proceedings of the National Academy of Sciences USA. .105(38): 14638-14643.
Oskowitz, A.Z., Lu, J., Penfornis, P., Ylostalo, J., McBride, J., Flemington, E.K., Prockop, D.J., and Pochampally, R. (2008) "Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression." Proceeding of the National Academy of Sciences USA. 105(47): 18372-18377.
Weiss, D.J., Kolls, J.K., Ortiz, L.A., Panoskaltsis-Mortari, A., and Prockop, D.J. (2008) "Stem cells and cell therapies in lung biology and lung diseases." Proceedings of the American Thoracic Society. 5(5): 637-667.
Ylöstalo, J., Bazhanov, N., and Prockop, D.J. (2008) "Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies." Experimental Hematology. 36(10): 1390-1402.
Spees, J.L., Whitney, M.J., Sullivan, D.E., Lasky, J.A., Laboy, M., Ylostalo, J., and Prockop, D.J. (2008) "Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension." FASEB Journal. 22(4): 1226-1236.
Lee, R. H., Seo M. J., Pulin A. A., Gregory C. A., Ylostalo, J. , and Prockop, D. J. (2009) "The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infracted heart in mice." Blood. 113(4):816-826.
Block, G.J., Ohkouchi, S., Fung, F., Frenkel, J., Gregory, C., Pochampally, R., Dimattia, G., Sullivan, D.E., and Prockop, D.J. (2009) "Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1". Stem Cells. 27(3): 670-681.
Prockop, D.J. (2009) "Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing Paradigms." Molecular Therapy. 2009 Mar 31. [Epub ahead of print].
