Gregory J. Bix, M.D., Ph.D.
Assistant Professor
Department of Molecular and Cellular Medicine
Room 426 Reynolds Medical Building
College Station, TX 77843
Phone:979-862-7613
Fax:979-847-9481
Email: gjbix@medicine.tamhsc.edu
Education
He received his B.A. (Summa Cum Laude with High Honors) in Neuroscience and Biology from Brandeis University in 1993, where he was elected to the Phi Beta Kappa Society. He earned his Ph.D. in Neuroscience from the Baylor College of Medicine in Houston in 1998 and his M.D. was awarded from the Baylor College of Medicine in 2000. From 2000-2001 he completed his pediatric internship at Baylor College of Medicine and in 2001 a fellowship in neurology at the Children’s Hospital of Philadelphia. He trained as a postdoctoral fellow at Thomas Jefferson University from 2002-2005. Then he became a Research Assistant Professor in 2006. Dr. Bix joined the faculty at Texas A&M University Health Science Center in 2007.
Research Interests
My lab is interested in the role of extracellular matrix in stroke, the third leading cause of mortality in the United States. Vascular matrix components are often very sensitive to proteolytic processing/degradation in models of focal cerebral ischemia. Often such processing will generate biologically active matrix fragments. One focus of our lab is to determine how select matrix fragments affect the neurovascular unit, the functional multicellular unit that is perturbed in stroke. Another focus of our lab is to determine what role these matrix fragments could play in neurodevelopment involving processes that are often recapitulated in response to CNS injury.
Selected Publications
Bix, G., Iozzo R., Woodall, B., Burrows, M., McQuillan A., Campbell, S., Fields, G., Iozzo., R.V. Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the α2β1 integrin. Blood. 109(9):3745-8, 2007.
Bix, G., Castello, R., Burrows, M., Zoeller, J., Weech, M., Iozzo, R., Cardi, C., Thakur, M., Barker, C.,Camphausen, K., Iozzo, R.Endorepellin In Vivo: Targeting the Tumor Vasculature and Retarding Cancer Growth and Metabolism. J. Nat. Canc. Inst. 98(22):1634-1646, 2006. *Selected by Faculty of 1000 in 2006 and rated as “Exceptional”.
Bix, G. and Iozzo, R.V. Matrix revolutions: ‘Tails’ of basement-membrane components with angiostatic functions. Trends in Cell Biol. 15(1):52-60, 2005.
Bix, G., Fu, J., Gonzalez, E.M., Macro, L., Barker, A.,Campbell, S., Zutter, M.M., Santoro, S.A., Kim, J.K., Hook, M., Reed, C.C., Iozzo, R.V. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin. J. Cell Biol. 166(1):97-109, 2004. *Highlighted in Nature Reviews Molecular Cell Biology, Aug., 2004 (vol. 5, No. 8). Selected by Faculty of 1000 in 2004 and rated as “Must read”.
