Lan H. Ly, Ph.D.
Assistant Professor
Microbial & Molecular Pathogenesis
407 Reynolds Medical Building
College Station,
Texas 77843-1114
Phone: 979-845-3679
Fax: 979-845-3479
Email: LHLy@medicine.tamhsc.edu
Education and Post-Graduate Training
B.S., University of California, San Diego (2000)
Ph.D., Texas A&M University (2004)
Post-Doc, Texas A&M College of Medicine (2010)
Research Interests
The formation and maintenance of granulomas undoubtedly plays a central role in the pathogenesis of tuberculosis. Although it is widely accepted that proper structural organization of the tuberculous granuloma to contain the bacilli is favorable to the host, it is now also thought to be detrimental to the host as it can result in collateral destruction of adjacent lung tissue in addition to providing a barrier to effective drug treatment. Given the central role of granuloma formation in the pathogenesis of pulmonary tuberculosis, my research interests involve examining the essential contributions of TNFα to granuloma formation and maintenance in the guinea pig model of tuberculosis.
Selected Publications
Ly, L.H. and McMurray, D.N. (2010) Contributions of the guinea pig model to the understanding of BCG vaccine-induced resistance to tuberculosis. (in press).
Bonilla, D.L, Ly, L.H., Fan, Y.Y., Chapkin, R.S., and McMurray, D.N. (2010) Incorporation of an omega-3 fatty acid impairs macrophage responses to Mycobacterium tuberculosis. Plos One 5(5): e10878.
McMurray, D.N and Ly, L.H. (2009) TB Vaccines: the paradigms they are a-shifting. Exp. Rev. Vaccines 8 (12): 1615-1618.
Ly, L.H. and McMurray, D.N. (2009) The Yin Yang of TNFα in the guinea pig model of tuberculosis. Ind. J. Exp. Bio 47: 432-439.
Ly, L.H., Jeevan, A., and McMurray, D.N. (2009) Neutralization of TNFα alters inflammation and granuloma formation in guinea pig tuberculous pleuritis. Microbes and Infection 11 (6-7): 680-688.
Ly, L.H. and McMurray, D.N. (2008) Tuberculosis: Vaccines in the Pipeline: Review. Expert Rev. Vaccines 7(5): 635-650.
Ly, L.H., Barhoumi, R., Franzblau, S., and McMurray, D.N. (2008). BCG vaccination promotes mycobacterial control in the guinea pig macrophages infected in vivo. J. Infect. Dis. 198 (5): 768-771.
Ly, L.H., Russell, M.I., and McMurray, D.N. (2008). Cytokine profiles differ between primary and secondary granulomas in the lungs of guinea pigs infected with virulent Mycobacterium tuberculosis. Am. J. Respir. Cell Mol. Biol. 38, 455-462.
Ly, L.H., Russell, M.I., and McMurray, D.N. (2007). Microdissection of the Cytokine Milieu of Pulmonary Granulomas from Tuberculous Guinea Pigs. Cellular Microbiology 9, 1127-1136.
