The faculty of the Department of Systems Biology & Translational Medicine provides instruction in medical and graduate courses.

Medical

First Year Students: Phase I and Phase II

MEID 920: Core Principles of Medicine (Phase I)

MEID 921: Core Principles of Medicine II (Phase I)

MEID 935: Introduction to Disease (Phase II)

MEID 936: Neuroscience (Phase II)

Second Year Students

MEID 955: Respiratory Block

MEID 956: Cardiovascular Block

MEID 957: Renal/GU Block

MEID 960: Endocrinology/Reproductive Sciene/Human Sexuality Block

Graduate

MSCI 601 PRINCIPLES OF BASIC MEDICAL SCIENCES. Molecular basis of cellular functions in human body: technologies for probing cellular functions and structures; plasma membranes and intracellular organelles; gene function; cell metabolism; cell motility and cytoskeleton.

MSCI 610 PATHOGENESIS OF HUMAN DISEASE. Cell injury, apoptosis and inflammation; immune system and allergies; cardiovascular, infectious, neurodegenerative and genetic diseases.

MSCI 612 CURRENT TOPICS IN CELL SIGNALING. The course provides an overview of intracellular signal transduction pathways utilized by various classes of growth factor, cytokine, integrin and G protein coupled receptors. The course also will provide a clear understanding of the importance of these pathways in regulating cell growth, differentiation, apoptosis and other cellular processes, both under normal physiologic conditions as well as diseases.

SBTM 601 EXPERIMENTAL TECHNIQUES IN MOLECULAR, CELL AND SYSTEMS BIOLOGY I. Fundamental laboratory techniques used to investigate cellular and subcellular structure and function; cell culture and isolation; light microscopy (brightfield, phase, DIC); fluorescence microscopy; confocal and multiphoton microscopy; atomic force microscopy; protein isolation, concentration and quantification; gel electrophoresis; immunoprecipitation; agarose gel electrophoresis; northern, southern and western blotting; transfections and plasmid preps; ELISA and multiplex analysis of cell-derived products.

SBTM 608 BONE BIOLOGY. Introduction to the discipline of bone; discussion includes all aspects of bone biology.

SBTM 612 EXPERIMENTAL TECHNIQUES IN MOLECULAR, CELL AND SYSTEMS BIOLOGY II. Molecular techniques including PCR, real-time PCR, microarrays, 2-D gels, HPLC, mass spectroscopy, flow cytometry, siRNA and transfections. Tissue techniques including intravital microscopy, single perfused vessels, papillary muscle/skinned fiber preparations, sectioning and staining, immunocytochemistry, in situ hybridization, laser capture microdissection, patch clamping; whole animal technologies including echo and other imaging modalities, animal models of human disease, transgenics, analysis of human tissues and system performance.

SBTM 613 HUMAN ORGAN SYSTEMS I. Structure and function of human organ systems. Introduction to the nervous system; musculoskeletal system; integumentary system; cardiovascular system. Interaction of organ systems in response to physiological stresses.

SBTM 614 HUMAN ORGAN SYSTEMS II. Structure and function of human organ systems. Nervous, respiratory, urinary, gastrointestinal, endocrine and reproductive systems. Interaction of organ systems in response to physiological stresses.

SBTM 615 PATHOBIOLOGY AND THERAPEUTICS. Overview of disease processes and therapeutics; problem-based, student-directed analyses of whole body responses to specific diseases, emphasizing interconnectivity of human organ systems and its importance in designing therapeutic strategies.

SBTM 624 COMPUTATIONAL SYSTEMS BIOLOGY: BIOSTATISTICS. Biostatistics including data distributions, significance tests, correlation and regression, analysis of variance

SBTM 625 COMPUTATIONAL SYSTEMS BIOLOGY: BIOINFORMATICS AND IMAGING. Bioinformatics including large data sets from sequencing and microarray experiments, Perl, BLAST and BLAT, databases and MySQL, GraphViz and Cytoscape, proteomics and physiomics, biocomputing and cluster computing; biomedical imaging including digital image formats, enhancements, feature extraction and quantification.

SBTM 681 SEMINAR. Focus will be on critical scientific thinking. Emphasis placed on oral communications, scientific writing and grant preparation.

SBTM 685 DIRECTED STUDIES. Limited investigation in fields other than those chosen for thesis or dissertation.

SBTM 689 SPECIAL TOPICS IN ... Selected topics in an identified area of system biology and translational medicine.