Jerry Trzeciakowski, Ph.D.
Professor
Vice Chairman
Systems Biology and Translational Medicine
310A Reynolds Medical Building
College Station,
TX 77843
Phone: 979-845-7816
Email: trzeciak@medicine.tamhsc.edu
Education and Post-Graduate Training
Post-doctoral research in Cardiovascular Pharmacology at Cornell University Medical College, New York
Research Interests
Quantifying cell surface texture
The Atomic Force Microscope (AFM) in scanning mode allows detailed examination of cell surfaces at nanoscale resolutions and can track changes in surface texture in response to physiological and pathophysiological stimuli. Texture characterization requires quantifying the overall degree of roughness (fractal dimension) as well as the distribution or clustering of roughness (lacunarity). Lacunarity is a confounding factor in roughness assessment; it is not scale-invariant and there is no established method to interpret the changes in scale dependence that occur as fractal dimension varies.
Predicting age-related renal damage and dysfunction
In collaboration with Dr. Alan Parrish, we are developing a model to allow assessment of the degree of renal damage based on measurese of a small number of indices of renal function such as BUN, KIM-1, urine volume and urine albumin. Early detection of renal disease in the aging population could potentially allow intervention and slow or prevent the progression of damage.
Selected Publications
Meininger GA, Trzeciakowski JP. Vasoconstriction is amplified by autoregulation during vasoconstrictor-induced hypertension. Am J Physiol 254:H709-H718, 1988. PMID: 3354698
Meininger GA, Trzeciakowski JP. Combined effects of autoregulation and vasoconstrictors on hindquarters vascular resistance. Am J Physiol H1032-H1041, 1990. PMID: 2330992
Trzeciakowski JP, Chilian WM. Polar symmetry plots. Mathematica J 4:61-66,1994. No PMID
Trzeciakowski JP. Analysis of stimulus-response chains using nonlinear dynamics. J Pharmacol Toxicol Methods 36:123-131, 1996. PMID: 8912229
Trzeciakowski JP. Stimulus amplification, efficacy and the operational model I: Binary complex occupancy mechanisms. J Theor Biol 198: 329-346, 1999. PMID: 10366490
Trzeciakowski JP. Stimulus amplification, efficacy and the operational model II: Ternary complex occupancy mechanisms. J Theor Biol 198: 347-374, 1999. PMID: 10366491
Trzeciakowski JP. A method for normalizing drug responses to enhance reliability of parametric statistical tests. J Pharmacol Toxicol Meth. 41: 75-82, 1999. PMID: 10598678
Avalos M, Mak C, Randall PK, Trzeciakowski JP, Abell C, Kwan SW, Wilcox RE. Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells. J Pharmacol Toxicol Meth 45: 17-37, 2001. PMID: 11489662
Trzeciakowski JP, Meininger GA. NForceR: Nanoscale Force Reader. Atomic Force Microscopy data acquisition and analysis software package. Copyright, 2004.
Trzeciakowski J, Chilian WM. Chaotic behavior of the coronary circulation. Med Bio Eng Comput, 46(5):433-442, 2008. No PMID
Botting SK, Trzeciakowski JP, Benoit M, Salama SA, Diaz-Arrastia CR. Sample entropy analysis of cervical neoplasia gene-expression signatures. BMC Bioinformatics 2009, 10:66 (20 February 2009) PMCID: PMC2656476
