Professor
Systems Biology and Translational Medicine
Surgery (Orthopedic Division)
Director, Basic Science Research, Center for Bone, Joint and Spine Research

702 Southwest H.K. Dodgen Loop
Temple, Texas 76504
Phone: 254-231-5340
Fax: 254-742-7145
Email: sampson@medicine.tamhsc.edu
Link to Vita

Education

Ph.D., Baylor University, 1970 (Anatomy)

Research Interests

Research in this laboratory is concerned with the broad spectrum of bone and mineral metabolism. The process of the initiation of mineralization and the effect of nutrition upon the development of osteoporosis are two major areas of concentration. We are presently using proteomic techniques with human bone samples to give new insight into the pathogenesis of osteoporosis and to develop a serum biomarker for osteoporosis. Our lab has been concerned for several years with the effect of long-term alcohol consumption on bone growth, maintenance and the development of osteoporosis. We are also concerned with the effect of alcohol on adolescent bone development, since the preteen and adolescent youth years are times of rapid bone growth in size and mass and are especially critical in young girls. More recent studies have been in collaboration with the orthopedic department at Scott & White studying the effect of alcohol on fracture healing using microarray techniques. A new area that we are pursuing is the role of osteocytes in mechanotransduction of bone and the signaling pathways involved. Teaching consists of Gross Anatomy and Embryology to the medical students, a graduate course in Bone Biology and lectures on Basic Bone Biology to the orthopedic residents. I also teach a course for nutrition graduate students on “How to present a Seminar”.

Selected Publications

Hogan, HA, SP Ruhmann, HW Sampson . The Mechanical Properties of Cancellous Bone in the Proximal Tibia of Ovariectomized Rats. J. Bone Miner. Res. 15:284-292 (2000).

Hogan, HA, F Argueta, L Moe, LP Nguyen, HW Sampson . Adult- Onset Alcohol Consumption Induces Osteopenia in Female Rats. Alcohol Clin. Exp. Res. 25:746-754(2001).

H. Wayne Sampson . Alcohol and Other Risk Factors for Osteoporosis. Alcohol Research & Health. 26: 292-298 (2002)

Sampson, HW, AC Dearman, AD Akintola, WE Zimmer, A Parrish. Immunohistochemical Localization of Cadherin and Catenin Adhesion Molecules in the Murine Growth Plate.  J. Histochem. Cytochem. 55(8):845-52 (2007).

H. Wayne Sampson, Alan R. Parrish, Alaina Dearman, Warren E. Zimmer. The Presence of p120 Catenin in Osteocytes and Other Bone Cells. J.Bone Mineral. Res. 22:S359 (2007).

C.D. Chaput,  M. D. Rahm, K. D. Hitt, D.S. Stewart, L.J. Dangott, H.W. Sampson. Protein Variation between Normal and Osteopenic Bone: A Proteomic Study of the Human Femoral Neck.  (submitted)