Wei Wang
Research Assistant Scientist
Department of Systems Biology and Translational Medicine
Phone: 979-739-7907
E-mail: weiwang@tamu.edu
Education
M.D., Medicine, 1984, China Medical University (PR China)
M.S., Medical Pathology, 1991, Nanjing Medical College (PR China)
Research Interests
The characteristic topographo-histological structure of the mesenteric lymphatics provides the body with a special entrance site for the macromolecular lipoproteins including the well-known cholesterol carrier, low-density lipoprotein (LDL). The intestinal lymph contains both the enterocyte-synthesized and plasma-derived lipoproteins. The blood lipoprotein level is affected by life styles and fluctuates with meal styles. The lipid absorption is associated with an alteration in the mesenteric lymph pressure and lymph flow. Thus the mesenteric lymphatics play an essential role in coordinating intestinal lymph transport with intestinal absorption by adjusting their pumping activities.
My research interests are mainly in the influences of LDL, mediated through the LDL receptor, nitric oxide (NO), superoxide, and electrophysiological activity, on the pumping activities of the mesenteric lymphatics.
The technical approaches include:
- To localize the LDL receptors, the endothelial NO synthase (eNOS), and the endocytosis of the LDL in the rat mesenteric lymphatics by the immunohistochemistry under the confocal microscope
- To measure the effect of LDL on the pumping activities of the lymphatic vessel by the Isolated Microlymphatic Functional Measurement.
- To determine the influence of LDL on membrane potential of the lymphatic muscle by microelectrode technique.
Understanding the influences and mechanisms of LDL on the pumping of the mesenteric lymphatics may help correlate the lymphatic function with a scientific basis for the potential prevention and treatment of the disorders related to lipoprotein metabolism.
Selected Publications
Wei Wang, Zhanna Nepiyushchikh, David C. Zawieja, Sanjukta Chakraborty, Scott D. Zawieja, Anatoliy A. Gashev, and Mariappan Muthuchamy. Inhibition of myosin light chain phosphorylation decreases rat mesenteric lymphatic contractile activity. Am J Physiol Heart Circ Physiol 2009; 297: H726-H734.
H. Glenn Bohlen, Wei Wang, Anatoliy A Gashev, Olga Y. Gasheva, and David C. Zawieja, PhD. Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo. Am J Physiol Heart Circ Physiol, 2009; 297: H1319-H1328.
Anatoliy A. Gashev, Michael J. Davis, Olga A. Gasheva, Zhanna Nepiyushchikh, Wei Wang, Patrick Dougherty, K. A. Kelly, S. Cai, P.-Y. von der Weid, Mariappan Muthuchamy, Meininger J. Cindy, and David C. Zawieja. Methods for lymphatic vessel culture and gene transfection. Microcirculation 2009 Jul 22:1-14.
Anatoliy A. Gashev, Wei Wang, Glen A. Laine, Randolph H. Stewart , and David C. Zawieja. Characteristics of the active lymph pump in bovine mesenteric lymphatics. Lymphatic Research and Biology 2007; 5(2):71-80.
Naris Thengchaisri; Travis W. Hein; Wei Wang; Xin Xu; Zhenbo Li; Theresa W. Fossum; Lih Kuo. Upregulation of Arginase by H2O2 Impairs Endothelium-Dependent Nitric Oxide-Mediated Dilation of Coronary Arterioles. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006; 26:2035.
Cuihua Zhang, Travis W. Hein, Wei Wang, Lih Kuo. Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. J Mol Cell Cardiol 2006; 40(2): 247-257.
Cuihua Zhang, Xiangbin Xu, Barry J. Potter, Wei Wang, Lih Kuo, Lloyd Michael, Gregory J. Bagby, William M. Chilian. TNF- alpha Contributes to Endothelial Dysfunction in Ischemia/Reperfusion Injury. Arterioscler Thromb Vasc Biol 2006;26:475.
Cuihua Zhang, Travis W. Hein, Wei Wang, Matthew W. Miller, Theresa W. Fossum, Michelle M. McDonald, Jay D. Humphrey, Lih Kuo. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension. 2004 Dec 44(6):935-43.
Travis W. Hein, Cuihua Zhang,, Wei Wang, and Lih Kuo. Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall. Circulation. 2004 Oct 26; 110(17):2708-12.
Travis W. Hein, Cuihua Zhang, Wei Wang, C.-I. Chang, N. Thengchaisri, and Lih Kuo. Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. FASEB J. 2003 Dec 17(15):2328-30.
Cuihua Zhang, Travis W. Hein, Wei Wang, Lih Kuo. Divergent Role of Angiotensin II AT1 and AT2 Receptors in Modulating Coronary Microvascular Function (Short title: Influence of Ang II on Coronary Arterioles). Circ Res. 2003 Feb 21; 92(3): 322-9.
Cuihua Zhang, Travis W Hein, Wei Wang, Chiung-I Chang and Lih Kuo. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J. 2001 May 15(7): 1264~6.
Travis W. Hein, Wei Wang, Behyar Zoghi, Mariappan Muthuchamy and Lih Kuo. Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 2001; 33: 271-282.
Wei Wang et al. A study of detecting precancerous lesion of liver in rat by combining plane-stereological morphology and AgNOR counting. Acta Academiae Medicinae Shuzhou. 1997; 17(4): 627.
Bo Xuan, Wei Wang, Dexin Li. Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. Acta Pharmacol Sin 1994; 15(2): 133.
Wei Wang et al. Effect of methyltestosterone on hepatocarcinogenesis initiated by diethylnitrrosamine in rat liver. Chinese Journal of Pathology 1993; 22(3): 186.
Bo Xuan, Dexin Li, Wei Wang. Protective effects of tetrahydroprotoberberines on experimental myocardial infarction of rats. Acta Pharmacol Sin 1992; 13(2): 167.
Wei Wang. A Case report of angiolymphoid hyperplasia with eosinophilia. Acta Academiae Medicinae Nanjing 1992; 12(4): 402.
