Research Interests:
The purpose of the work in my laboratory is to elucidate mechanisms of carcinogenic signal transduction and of susceptibility to tumor promoter-induced transformation. The first research program (program 1) focuses on carcinogenic signal transduction by investigating mechanisms of gene regulation in carcinogenesis. The second research program (program 2) focuses on identification of determinants of acquired and inherited susceptibility to neoplastic transformation.

Microarray Paper Data

Representative Publications:
Walker, S,. and Bernstein, L.R. "AP-1 Oligonucleotides Derived from Different TPA-inducible effector genes have distinct patterns of induction in JB6 cells ensitive and resistant to tumor promoter-induced transformation: potential omportance of flanking sequences,"American Association for Cancer Rsearch Annual Meeting, 39, 249, 1998.

Denning, T., Ferris, D.K., and Berstein, L.R., Biochemical and functional analyses of MAP kinase-related proteins that form complexes in vivo with AP-1' thanscriptioin factors. 9th International Congress on Genes, Gene Families and Isozymes 86, 1997.

Lin, H.K., Berstein, L.R. Penning, T.M. Transcriptional Regulation of a Human dihydrodiol dehydrogenase gene by reactive oxygen species involves AP-1 activation. American Association for Cancer Research Meeting, Washington DC, May 1996.

Watts, B., Ben-Ari, E.T., Bernstein, L.R., Birrer, M.J., and Colburn, N.H. C-jun and Multistage Carcinogenesis: Overexpresses c-jun Transforms Promotion Sensitive but Not Promotion-Resistant Cells and Does Not confer Promotion Sensitivity. Molecular Carcinogenesis 13, 27-36, 1995.

Bernstein, L.R., and Liotta, L.A. Metastasis and Angiogenesis, A Review. Current Opinion in Oncology 6, January, 1994.

Bernstein, L.R., Ferris, D.K., Colburn, N.H., and Sobel, M.E. A Family of MAP Kinase-Related Proteins Interacts In Vivo With the AP-1 Transcription Factor, Journal of Biological Chemistry 269, Communication, 9401-9404, April 1, 1994.

Bernstein, L.R., Bravo, R., and Colburn, N.H. 12-0-Tetradecanoylphorbol-13-acetate-Induced Levels of AP-1 Proteins: A 46 kDa protein Immunoprecipitated by anti Fra-1 and Induced in Promotion-Resistant but Not Promotion-sensitive JB6 Cells. Molecular Carcinogenesis 6, 221-229, 1992.

Ben-Ari, E.T., Bernstein, L.R., and Colburn, N.H. Differential c-jun Expression in Response to Tumor Promoters in JB6 Cells Sensitive or Resistant to Neoplastic Transformation. Molecular Carcinogenesis 5, 62-74. 1992.

Bernstein, L.R., and Colburn, N.H. AP-1/jun Function is Differentially Induced in Promotion Sensitive and Resistant JB6 Cells. Science 244: 566-569, 1989.