Go to content Go to site map

Jing Pan, M.D., Ph.D.

Skip breadcrumb navigation

Assistant Professor
Department of Internal Medicine - Division of Molecular Cardiology

1901 S. 1st Street, Bldg. 205, Office #1R29
Temple, TX 76504
Phone: (254) 743-2461
Fax: (254) 743-0165
Email: jpan@medicine.tamhsc.edu
Curriculum Vitae (PDF)

Education and Post-Graduate Training

M. D.:  Shanxi Medical University, Shanxi Province, P. R. China, 1987

Ph.D.: Beijing Medical University of China, 1994

Post Doc Training: Keio University of Japan, 1995-1999 

Cardiovascular Research Institute, Texas A&M HSC COM, Temple, Texas, 2000-2002

Research Interests

My general research interests include molecular mechanisms of cardiac remodeling, role of retinoic acid receptors mediated signaling, the association between retinoic acid receptor and KLF5, NF-kβ in cardiac remodeling, and role of retinoic acid receptors in regulation of renin-angiotensin system.  I am currently exploring the underlying molecular mechanisms of retinoic acid receptor mediated signaling in diabetes-induced cardiac remodeling and the regulatory mechanism of renin-angiotensin system by retinoic acid receptors, utilizing both in vitro and in vivo systems.  I am also investigating the molecular mechanisms of osteoporosis in diabetes.  A combination of genetic, molecular biology and biochemistry, transgenic and cell culture systems to comprehensively investigate and elucidate the underlying molecular mechanisms of cardiac remodeling is being used in this research and this project is being funded by NIH and Scott & White.

Selected Publications

Guleria R, Choudhary R, Tanaka T, Baker KM, Pan J.  Retinoid Acid Receptor-Mediated Signaling Protects Cardiomyocytes from Hyperglycemia-induced Apoptosis:  Role of the Renin-Angiotensin System.  Diabetes.  In Review.

Kumar R, Baker KM, Pan J.  Cardiac and Vascular Renin-Angiotensin systems in:  Hypertension and Hormone Mechanisms, First Edition, P. Michael Conn, Ed., The Humana Press, Inc. (In Press)

Choudhary R, Baker KM, Pan J.  All-Trans Retinoic Acid prevents Angiotensin II- and Mechanical Stretch-Induced Reactive Oxygen Species Generation and Cardiomyocyte Apoptosis.  J Cell Physiol 2007 Oct 16 [Epub ahead of print]

Joshi S, Guleria RS, Pan J, DiPette D, Singh US.  Heterogeneity and Retinoic Acid Signaling in Neuroblastomas:  Role of Matrix Metalloproteinases in Retinoic Acid-Induced Differentiation.

Pan J, Baker KM.  Retinoic Acid and Cardiovascular System.  Vitam Horm.  2007;75:257-83.

Pan J, Baker KM.  Angiotensin Signaling in Hypertension.  "Molecular Mechanisms of Hypertension" First Edition.  D DiPette, E Schiffrin, J Sowers, R Re Eds., Taylor & Francis Publishers, Inc. 15-23, 2006.

Guleria RS, Pan J, DiPette D, Singh US.  Hyperglecemia Inhibits Retinoic Acid-Induced Actiation of rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy.  Diabetes 55(12):3326-34, 2006.

Joshi S, Guleria RS, Pan J, Bayless KJ, Davis GE, DiPette D, Singh US.  Ethanol Impairs Rho GTPase Signaling and Differentiation of Cerebellar Granule Neurons in a Rodents Model of Fetal Alcohol Syndrome.  Cell Mol Life Sci, 63(23):2859-70, 2006.

Joshi S, Guleria R, Pan J, DiPette D, Singh US.  Retinoic Acid Receptors and Tissue-Transglutaminase Mediate Short-Term Effect of Retinoic Acid on Migration and Invasion of Neuroblastoma SH-SY5Y Cells.  Oncogene 12;25(2):240-7, 2006.

Pan J, Kao Y, Joshi S, Jethendran S, DiPette D and Singh US.  Activation of Rac1 by Phosphatidylinositol 3-Kinase in vivo:  Role in Activation of the MAP Kinase Pathways and Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Cells.  J Neurochem 93(3):571-583, 2005.

Singh US, Pan J.  Transglutaminase and Cell-Survival Signaling.  In metha K, Eckert R, eds. Transglutaminases:  Family of Enzymes with Diverse Function.  Prog Exp Tum Res. Basel, Karger, vol 38, 75-88, 2005.

Additional Publications

Pan J, Singh US, Takahashi T, Oka Y, Palm-Leis A, herbelin BS, Baker KM.  PKC Mediates Cyclic Stretch-Induced Cardiac Hypertrophy Through Rho Family GTPases and mitogen-Activated Protein Kinases in Cardiomyocytes.  J Cell Physiol 202(2):536-53, 2005. 

Palm-Leis A, Singh US, Herbelin BS, Olsovsky GG, Baker KM, Pan, J.  Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases Mediate the Inhibitory Effects of All-rans Retinoic Acid on the Hypertrophic Growth of Cardiomyocytes.  J Biol Chem 279(52):54905-17, 2004. 

Pan J, Singh SU, Kao Y, Joshi S, Young KL and Baker KM. Tissue-Transglutaminase Mediates Activation of RhoA and MAP Kinase Pathways During Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Cells. J Biol Chem 278:391-99, 2003.

Kodama H, Fukuda K, Pan J, Sano M, Takahashi T, Kato T, Makino S, Manabe T, Murata M, Ogawa S. Significance of ERK Cascade Compared with JAK/STAT and PI3-K Pathway in gp130-Mediated Cardiac Hypertrophy. Am J Physiol Heart Circ Physiol 279(4):H1635-644, 2000.

Sano M, Fukuda K, Kodama H, Pan J, Saito M, Matsuzaki J, Takahashi T, Makino S, Kato T, Ogawa S. Interleukin-6 Family of Cytokines Mediate Angiotensin II-Induced Cardiac Hypertrophy in Rodent Cardiomyocytes. J. Bio. Chem 2000.

Manabe T, Fukuda K, Pan J, Nagasaki K, Yamaguchi K, Ogawa S. Hypertrophic Stimuli Augment Expression of cMG1/ERF-1, a Putative Zinc-Finger Motif Transcription Factor, in Rat Cardiomyocytes. FEBS Lett. 463(1-2):39-42, 1999.

Takahashi T, Fukuda K, Pan J, Kodama H, Sano M, Makino S, Kato T, Manabe T, Ogawa S. Characterization of Insulin-Like Growth Factor-1-Induced Activation of the JAK/STAT Pathway in Rat Cardiomyocytes. Circ. Res. 85(10):884-91, 1999.

Pan J, Fukuda K, Saito M, Matsuzaki J, Kodama H, Sano M, Takahashi T, Kato T, Ogawa S. Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes. Circ. Res. 84(10):1127-1136, 1999.

Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S. Cardiomyocytes can be Generated from Marrow Stromal Cells in vitro. J. Clin. Invest. 103(5):697-705, 1999.

Pan J, Fukuda K, Kodama H, Sano M, Takahashi T, Makino S, Kato T, Manabe T, Hori S, Ogawa S. Involvement of gp130-Mediated Signaling in Pressure Overload-Induced Activation of the JAK/STAT Pathway in Rodent Heart. Heart Vessels 13(4):199-208, 1998.

Kodama H, Fukuda K, Pan J, Makino S, Sano M, Takahashi T, Hori S, Ogawa S. Biphasic Activation of the JAK/STAT Pathway by Angiotensin II in Rat Cardiomyocytes. Circ. Res. 82(2):244-50, 1998.

Kodama H, Fukuda K, Pan J, Makino S, Baba A, Hori S, Ogawa S. Leukemia Inhibitory Factor, a Potent Cardiac Hypertrophic Cytokine, Activates the JAK/STAT Pathway in Rat Cardiomyocytes. Circ. Res. 81(5):656-663, 1997.

Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, Hori S, Ogawa S. Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart. Circ. Res. 81(4):611-617, 1997.

National Service/Recognition

Japanese Circulation Society member - 1996-99

American Heart Association member - 1996-present

Japan Society for the Promotion of Science in Research Fellowship Program, Tokyo, Japan - 1997-98

Best Poster Award, 2nd Cardiovascular Research Institute Research Retreat, Texas - 2006

Editorial Reviewer:   Circulation, The American Journal of Physiology, Journal of Molecular and Cellular Cardiology and Basic & Clinical Pharmacology & Toxicology