Troy A. Baudino, Ph.D.

TAMHSC Arrows COM Arrows Clinical Departments Arrows Internal Medicine Arrows Molecular Cardiology Arrows Faculty and Staff Arrows Troy A. Baudino, Ph.D.

Associate Professor
Internal Medicine

1901 South 1st Street
Temple, Texas 76504
Phone: 254-743-0996
Fax: 254-743-0165
Email: tbaudino@medicine.tamhsc.edu
Curriculum Vitae (PDF)

Education and Post-Graduate Training

B. S., Biology, Bradley University, Peoria, Illinois, 1989-1993

Ph.D., Cell and Molecular Biology, St. Louis University, St. Louis, Missouri, 1995-1999

Post-doctoral fellow, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee - 2000-2004

Research Interests

Our research explores cell-cell interactions and how those relate to maintaining normal cardiac function, as well as how those interactions are altered during pathological insult. In addition, my laboratory is interested in understanding how the cardiac cell populations change during development and disease and how these changes relate to cardiac function.

Normal cardiac function requires the interaction of various cell types including myocytes, fibroblasts, pericytes, smooth muscle cells and endothelial cells, as well as components of the extracellular matrix (EMC). Proper organization of these cellular and acellular components is necessary to respond to a variety of physiological and pathophysiological signals. During physiological or pathophysiological cardiac growth, proper balance between angiogenesis and growth is necessary for maintenance of cardiac function. While studies have examined the role of matrix metalloproteinases, cytokines, and growth factors, none have examined the significance of cell-cell interactions during vascular remodeling in the heart. Cardiac fibroblasts play a critical role in maintaining normal cardiac function, as well as in cardiac remnodeling during pathological conditions such as myocardial infarction and hypertension. These cells have numerous functions, including snythesis and deposition of ECM, cell-cell communication with myocytes, cell-cell signaling with other fibroblasts, as well as with endothelial cells. These contacts can affect electrophysiological properties, secretion of growth factors and cytokines, as well as potentiation of blood vessel formation. While information is known about several of these processes, little is understood about the role of fibroblasts in mediating angiogenesis during cardiac development and remodeling. This is a main focus of our laboratory.

In addition, we are interested in the interactions between cardiac fibroblasts, myocytes and the ECM. The specific arrangement of the cellular components of the heart is critical for communication by chemical, mechanical and electrical signals. We use several different mouse models that show changes in cell number, ECM content and physiological parameters to examine the hypothesis that interaction between myocytes, fibroblasts and the ECM is critical in the regulation of cardiac growth and remodeling during both normal and adaptive situations. The interaction between fibroblasts and myocytes, which is regulated by mechanical and chemical signals, is essential to the proper form and function of the heart.

The overarching goal of the laboratory is to identify therapeutic targets for attenuation of adverse remodeling following cardiac injury preventing the development of heart failure.

Research Support

NIH/NIDDK: ruth L. Kirschstein F32 National Research Service Award: Survival pathways in definitive hematopoiesis; 7/1/01-12/31-03
NIH: Dynamic interaction between cardiac fibroblasts, myocytes and the ECM; 4/01/08-3/31/13
AHA: Defining the role of myc during cardiac development and disease; 1/01/08-12/31/11

Selected Publications

Bowers SLK, Borg TK and Baudino TA. Dynamics of fibroblast-myocyte-capillary actions in the heart. Ann NY Acad Sci, 2010 Feb;1188:143-152.

Fuseler JW, Bedenbaugh BA, Yekkala K and Baudino TA. Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc^Min/+mice. Microscop Microanal, 2010 Feb;16(1):73-9. Epub 2009 Dec 24, PMID: 20030910.

Banerjee I, Fuseler JW, Souders C, Bowers SLK and Baudino TA. The role of interleukin-6 in the formation of the coronary vasculature. Microscop Microanal, 2009 Oct;15(5):415-21. Epub 2009 Aug 27. PMID: 19709461.

Banerjee I, Fuseler JW, Intwala AR and Baudino TA. IL-6 loss causes ventricular dilation, fibrosis, reduced capillary density and dramatically alters the cell populations of the heart. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H16940704. Epub 2009 Feb 20. PMID:19234091.

Norris RA, Borg TK, Butcher JT, Baudino TA, Banerjee I and Markwald RR. Neonatal and adult cardiovascular pathophysiological remodeling and repair: Developmental role of periostin. Ann NY Acad Sci, 2008 Mar; 1123:30-40. PMID: 18375575.

Yekkala K and Baudino TA. Inhibition of intestinal polyposis with reduced angiogenesis in Apc^Mice/+ mice due to decreases in c-Myc expression. Mol Cancer Res 2007 Dec;5(12):1296-1303. Erratum in Mol Cancer Res 2008 Feb;^(2):340. PMID: 18171987.

Baudino TA, McFadden A, Fix C, Hastings J, Price R and Borg TK. Cell patterning: interaction of cardiac myocytes and fibroblasts in 3 dimensional culture. Microsc Microanal, 2008 Apr 14(2):117-125. Epub 2008 Mar 3. PMID: 18312716.

Banerjee I, Fuseler J, Price R, Borg TK and Baudino TA. Determination of cell type and number during cardiac development in the neonatal and adult rat and mouse. Am J Physiol Heart Circ Physiol, 2007 Sept; 293:H1883-1891. Epub 2007 Jun 29. PMID: 17604329.

Banerjee I, Yekkala K, Borg TK and Baudino TA. Dynamic interactions between myocytes, fibroblasts, and extracellular matrix. Ann NY Acad Sci 2006 Oct; 1080:76-84. Review. PMID: 17132776.

Baudino TA, Carver W, Giles W and Borg TK. Cardiac fibroblasts: friend or foe? Am J Physiol Heart Circ Physiol, 2006 Sep;291(3):H1015-1026. Epub 2006 Apr 14. Review. PMID: 16617141.

Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL and Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1 responsive gene expression. EMBO J, 2005 Nov 16; 24(22):3846-3858. Epub 2005 Oct 20. PMID: 16237459.

Nilsson JA,Keller UB, Baudino TA, Yang C, Norton S, Brennan JA, Neale G, Porter CW, Kramer DL and Cleveland JL. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell, 2005; 7:433-444.

Davidoff AM, Ng CYC, Zhang Y, Streck CJ, Mabry S, Barton SH, Baudino TA, Zhou J, Kerbel RS, Vanin EF and Nathwani AC. Careful decoy receptor tittering is required to inhibit tumor angiogenesis while avoiding adversely altering VEGF bioavailability. Mol Ther, 2005 Feb; 11(2):300-310. PMID: 15668142.

Nilsson JA, Maclean KH, Keller UB, Pendeville H,, Baudino TA and Cleveland JL. Mnt loss triggers Myc transcription targets, proliferation, apoptosis and transformation. Mol Cell Biol 2004 Feb; 24(4):1560-1569. PMID: 14749372.

Kwon IK, Wang R, Prakash N, Bozard R, Baudino Ta, Liu K, Thangaraju M,Dong Z, Browning DD. Cyclic 3'.5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia. Cancer

2011 May, doi: 10.1002/cncr.26192. PMID: 21563174.

Davis C, Price R, Acharya G, Baudino T, Borg T, Berger FG, Pena MM. Hematopoietic derived cell infiltration of the intestinal tumor microenvironment in Apc Min/+ mice. Microsc Microanal. 2011 Aug;17(4):528-39. Epub 2011 Apr 8. PMID: 21473808.

Borg TK, Baudino TA. Dynamic interactions between the cellular components of the heart and the extracellular matrix. Borg TK, Baudino TA. Pflugers Arch 2011 Jul:462(1):69-74. Epub 2011 Mar 12. PMID: 21399896.

Bowers SL, Baudino TA. Laying the groundwork for growth: Cell-cell and cell-ECM interactions in cardiovascular development. Birth Defects Res C. Embryo Today. 2010 March;90*1):1-7. Review. PMID: 20301223.

Souders CA, Bowers SL, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res 2009 Dec 4;105(12):1164-76. Review. PMID: 19959782.

Bowers SL, Banerjee I, Baudino TA. The extracellular matrix: at the center of it all. J Mol Cell Cardiol. 2010 Mar;48(3):474-82. Epub 2009 Aug 31. Review. PMID: 19729019.

Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Old JA,Nilsson LM, Neale G, Kramer DL, Porter CW, Cleveland JL. Cancer Cell. 2005 May;7(5):433-44. PMID: 15894264.

National Service/Recognition

Excellence in Research Award, Bradley University, Peoria, Illinois - 1993

Monsanto Research Award, Monsanto/Searle, St. Louis, Missouri, 1995

Young Investigator's Award and Oral Presentation, Vitamin D Workshop, Strasbourg, France - 1997

Plenary Poster Presentation, ASBMR, San Francisco, California - 1998

Young Investigator's Award and Oral Presentation, ASBMR, St. Louis, Missouri - 1999

Individual NRSA Training Grant - 2001-2004

Young Investigator's Award, Keystone Symposia, Banff, Alberta, Canada - 2003

USC Research Advancement Award - 2008