Ph.D: School of Medicine, University of Southampton, United Kingdom (2011)
FRCSI: Royal College of Surgeons of Ireland (2010)
FACS: American College of Surgeons, USA (2008)
MMedSci: University of Glasgow, Scotland, United Kingdom (2000)
MRCS: Royal College of Physicians and Surgeons of Glasgow (2000)
Post-Graduate Training & Appointments
Visiting Postdoctoral Fellow, Centre for Human Development and Health, University of Southampton, United Kingdom (2008 till present)
Pediatric and Congenital Cardiothoracic Fellowship, Children’s Westmead Hospital, University of Sydney, NSW, Australia (2010-2011)
Complex Adult Cardiothoracic Fellowship, St Vincent’s Hospital, Melbourne, Vic, Australia (2008-2009)
Higher Surgical Adult Cardiothoracic Training, United Kingdom (2002-2007)
Basic Surgical Training, United Kingdom (1999-2001)
BUPA/ BHF Clinical Research Fellow, University of Southampton, United Kingdom (2005-2007)
Postgraduate Fellow, University of Glasgow, Scotland, United Kingdom (1998-2000)
Dr Elahi’s research includes investigating the role of blood-dependent redox activity and the biology of Nitric Oxide (NO) modulation in ischemia-reperfusion induced organ injury during extracorporeal circulation in ischemic heart disease. This has led to the Oxidative- Nitrosative Disequilibrium Hypothesis in collaboration with his British collaborator Dr Bashir Matata (FRS-Med) from the Liverpool Heart & Chest Hospital and University of Liverpool in United Kingdom and the invention of surrogate miniature cardiopulmonary bypass circuit.
Dr Elahi is also examining the effects of genes encodings and polymorphisms in the promoter regions of the Tumour Necrosis Factor in ethnicity-specific risk of cardiovascular disease; defining gene silencing for gene therapy in preventing early origins of atherosclerosis, and studying the usage and implications of endothelial progenitor cells in tissue engineering models of heart/ lung transplant and mechanical circulatory support.
More recently, Dr Elahi has developed a unique mouse model where offspring of obese mothers develop a phenotype similar to human cardiovascular and metabolic syndrome (i.e. a clustering of cardiometabolic risk factors that include obesity and having fatty liver, elevated blood pressure, insulin resistance and glucose intolerance, dyslipidemia, being in a proinflammatory and prothrombic state). He is currently investigating the mechanisms and therapeutic modulation of developmental programming of cardiovascular disease, in particular the influence of oxidative stress associated with maternal hypercholesterolemia, obesity and insulin resistance; the role of maternal adaptive immunity for in utero programming of postnatal humoral and cellular immune responses and expression of genes regulated by oxidation-sensitive pathways. The goal is to identify mitochondrial modulations, epigenetic modifications and endothelial dysfunction that could lead to early origins of heart disease in humans and to explore various therapeutic targets for the prevention of in utero programming of cardiovascular disease, insulin resistance, NIDDM, and aging. In this respect, his preliminary work in mice model demonstrated that statin treatment in hypercholesterolemic pregnant dams reduces cardiovascular risk factors in their offspring.
His research group comprises both clinical and laboratory researchers of national and international reputation (i.e. United Kingdom and Australia) as well as postgraduate and medical students. Potential academic collaborators, postgraduate and medical students who are interested in joining his group are encouraged to contact Dr Elahi.
Hypercholesterolemic-mediated Teratogenesis: Materno-Fetal Cholesterol Hypothesis of Cardiovascular Disease”LAP LAMBERT Academic Publishing GmbH & Co. KG (in press) Authors: Maqsood M Elahi, Bashir M Matata
“The Molecular Basis for the Link between Maternal Health and the Origin of Fetal Congenital Abnormalities: An Overview of Association with Oxidative Stress”, Bentham Science Publishers Ltd, Illinois, USA, 2011 Editors: Bashir M Matata, Maqsood M Elahi.
“Oxidative Stress: A Focus on Cardiovascular Disease Pathogensis” Nova Science Publishers Inc, USA 2010 Editors: Bashir M Matata, Maqsood M Elahi.
The Oxidative Stress: Clinical and Biomaterial Implications” Nova Science Publishers Inc, New York, USA, 2007 Editors: Bashir M Matata, Maqsood M Elahi.
Lanham SA, Roberts C, Hollingworth T, Sreekumar R, Elahi MM, Cagampang FR, Hanson MA, Oreffo RO. Maternal high-fat diet: effects on offspring bone structure. Osteoporos Int. 2010; 21: 1703-1704
Elahi MM, Worner M, Khan JS, Matata BM. Inspired nitric oxide and modulation of oxidative stress during cardiac surgery. Curr Drug Saf. 2009 Sep;4(3):188-98.
Elahi MM, Asotra K, Matata BM, Mastana SS. Tumour Necrosis Factor Alpha-308 Gene Locus Promoter Polymorphism: An Analysis of Association with Health and Disease. Biochim Biophys Acta. 2009 Biochim Biophys Acta. 2009 Mar;1792(3):163-72
Elahi MM, Cagampang FR, Mukhtar D, Anthony FW, Ohri SK, Hanson MA. Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr. 2009:1-6. 102(4):514-9.
Elahi MM, Kong YX, Matata BM. Oxidative stress as a mediator of cardiovascular disease. Oxidative Medicine & Cellular Longivity 2009; 2: 259-69.
Elahi MM, Yii M, Matata BM. Significance of oxidants and inflammatory mediators in blood of patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2008; 22: 455-67.
Elahi MM, Flatman S, Matata BM. Tracing the origins of postoperative atrial fibrillation: the concept of oxidative stress-mediated myocardial injury phenomenon. Eur J Cardiovasc Prev Rehabil. 2008;15 : 735-41.
Elahi MM, Matata BM. Functional adaptation to oxidative stress by memory T cells: An analysis of the role in the cardiovascular disease process. Biochem Biophys Res Commun. 2008; 376: 445-7.
Elahi MM, Cagampang FR, Anthony FW, Curzen N, Ohri SK, Hanson MA. Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring. Hypertension 2008; 51: 939-44
Elahi MM, Gilmour A, Matata BM, Mastana SS. A variant of position -308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease. Heart Lung Circ. 2008; 17(1):14-8.
Elahi MM, Naseem KM, Matata BM. Nitric Oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease. FEBS J. 2007; 274: 906-23
Elahi MM, Asopa S, Matata BM. NO-cGMP and TNF-α Counter Regulatory System in Blood: Understanding the Mechanisms Leading to Myocardial Dysfunction and Failure. Biochemica Biophysica Acta, 2007; 1772: 5-14
Elahi MM, Matata BM. Myocardial Protection against Ischemia-Reperfusion Injury: Novel Approaches in Maintaining Homeostatic Stability in Blood. Recent Patents on Cardiovascular Drug Discovery 2006; 1 (3): 291-305
Elahi MM, Matata BM. Is there a role of free radicals in the systemic inflammatory reaction? JCardiothoracic-Renal Res 2006; 1: 131-133
Elahi M, Matata B. Nitric Oxide-dependent Pathway Regulates Granulocytes Cytokines Release in Cultured Human Leucocytes from Type-II Diabetes Mellitus. Proceedings of the 13th Biennial Congress of the International Society for Free Radical Research, 2006: 115-118
Elahi MM, Matata BM, Hakim NS. Quiescent Interplay Between Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α: Influence on Transplant Graft Vasculopathy in Renal Allograft Dysfunction. Exp. Clinical Transpl, 2006; 1: 445-450
Elahi MM, Matata BM. Free Radicals in Blood: Evolving Concepts in the Mechanism of Ischaemic Heart Disease. Arch Biochem Biophys, 2006; 450: 78-88
Elahi MM, Matata BM. Blood-Dependent Redox Activity During Extracorporeal Circulation in Health and Disease. The Cardiology, 2005;1:156-157.
Elahi MM, Elahi M, Matata BM. Reactive Oxidant Species Augment Complement Function in Human Blood independently of Classical and MBL-Pathways. Int J Mol Med Adv Scien, 2005; 1: 382-391.
Elahi MM, Matata BM. Genetic Diversity of Tumour Necrosis Factor: Implications on Cardiovascular Complications of Polymorphisms at Position –308 in the Promoter Region. The Cardiology, 2005; 1: 179-188.
Elahi MM, Courtney JM, Matata BM. The Interaction between Reactive Oxidant Species and Proinflammatory Cytokines in Human Blood during Extracorporeal circulation. Filtration 2005; 1: 89-94
Elahi MM, Khan JS, Matata BM. Deleterious Effects of Cardiopulmonary Bypass in Coronary Artery Surgery and Scientific Interpretation of Off-pump’s Logic. Acute Card Care, 2006; 8: 196-209
Elahi MM, Battula NR, Hakim NS, Matata BM. Acute Renal Failure in Patients with Coronary Heart Disease: Causes and Novel Approaches for Breaking the Cycle of Self-Perpetuating Insults Abrogated by Surgery. Int Surg, 2005; 90: 202-208