September

From the Dean

Colleagues, Faculty, Staff and Students,

Shomaker Another month has flown by, and I appreciate your continued service to the College of Medicine. As we prepare for the next legislative session over the coming months, I encourage you all to be mindful of our resources. I cannot emphasize enough the importance of stewardship of our finances and resources. We absolutely must work together and work wisely to maximize each program, activity and opportunity not only for our students, but for our communities as well.

We also have to work hard to diversify our revenues so as to reduce our over-dependence on state dollars. This will require creativity and entrepreneurship from people across our organization. I encourage those of you that have ideas on how we can save money or increase revenue to share them with me by email (shomaker@medicine.tamhsc.edu), phone (979-436-0205) or by stopping by my office on the third floor of the Health Professions Education Building on State Highway 47 in Bryan. If my door is open, I am available. I also want to commit to you that I will be very transparent about the fiscal challenges we are facing and how we intend to address them. This is in keeping with my philosophy of leadership and is consistent with my belief that it is better to share more information with those who will be impacted by the challenges we face as an organization.

I’d like to take a moment to speak about the importance of public service, especially in medicine. Recently, I’ve had an essay selected by Academic Medicine, the journal of the AAMC, as one of the essays of the year. As such, I’ll be making a couple of national presentations, including a presentation at the AAMC national meeting in November, on “The Medical Marshall Plan: Rebuilding Public Trust in American Medicine,” and I will share that presentation with faculty, staff and students.

Much has happened in the past month, and as you read this newsletter, take a moment to thank or congratulate your colleagues and students for their hard work. Another successful Summer Research Program was hosted by the Office of Research. From first- to fourth-year, our students are organizing and volunteering at more health fairs in our campus communities. Our signature community outreach program, Mini-Medical School, is about to kick-off in Round Rock for the first time; and for the third year, one of our faculty is reaching out to young girls interested in science. All this and more is happening, and I thank you in advance for your continued hard work.

Please note the upcoming events, and I encourage you to keep up the great work that you are doing for your departments and for the college.

Sincerely,

T. Sam Shomaker, M.D., J.D.

The Jean and Thomas McMullin Dean
Texas A&M Health Science Center College of Medicine

Dates to Remember

Executive Committee Meeting: October 7, 3-4 p.m., various locations
Dean's Bi-Weekly Staff Meeting: October 12, 9:00 a.m., all locations
Basic Science Department Chair Meeting: October 14, 12-1:30 p.m., HPEB 3047B and Temple

College News

ANNUAL SUMMER RESEARCH PROGRAM HOSTS BEST AND BRIGHTEST FROM ACROSS NATION

The College of Medicine hosted its annual Summer Research Program on Wednesday, August 18 at the Joe H. Reynolds Medical Building.

The program kicked off at 9:00 a.m., and a group of more than 100 students, professors and mentors discussed projects on leukemia, prostate cancer, Alzheimer’s disease and autism spectrum disorder among others.

SRP Director Dr. Warren Zimmer presented the Dean’s Recognition Awards
to one undergraduate student and two second-year medical students for their outstanding research projects.

See the full article at News

MINI-MEDICAL SCHOOL KICKS OFF IN ROUND ROCK IN OCTOBER

For the first time, the College of Medicine invites the Round Rock community to Mini-Medical School at the Round Rock Campus from Thursday, October 7 to November 11, 2010.

College of Medicine Dean Dr. Sam Shomaker will kick off the series with a lecture about past, present and future medical education. The next week, HSC President Dr. Nancy W. Dickey will speak about the growth of health professions education at the HSC and elsewhere and the implications for education and patient care in the anticipated changes of health system reform.

Visit Mini-Medical School for more information.

CME IS UNDERWAY IN ROUND ROCK

Continuing Medical Education activities are underway in Round Rock under the direction of Courtney Dodge M.P.H., the College of Medicine’s Director of Continuing Medical Education and Graduate Medical Education (CME-GME). Since February, Dodge has worked toward the college’s accreditation as a CME provider.

NEW STAFFER JOINS HUMANITIES DEPARTMENT

A.J. Stramaski joined the Department of Humanities in Medicine in August as the new Education Program Coordinator. A.J. will be transitioning to support the Humanities Curriculum, so from time to time you may be hearing from him. We are pleased to have A.J. with us and we look forward to your meeting him. Welcome, A.J.!

Faculty

TRACHE GEARS UP FOR 3RD ANNUAL SATURDAY MORNING BIOPHYSICS PROGRAM

Dr. Andreea Trache, Assistant Professor of Systems Biology and Translational Medicine, is gearing up for her 3rd Annual Saturday Morning Biophysics Program for young girls beginning September 25. The program is co-sponsored by the Girl Scouts Bluebonnet Council and is subsidized by Dr. Trache’s NSF CAREER Award.

It was also featured by the National Science Foundation in May as a “National Lab Day Exemplary Project.”

Check out News for the upcoming article.

PROCKOP AND TEAM PUBLISH IN PNAS

Dr. Darwin Prockop, Director of the Institute of Regenerative Medicine and holder of the Stearman Chair in Genomic Medicine, and his team have published “The anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury” in Proceedings of the National Academy of
Sciences (PNAS).

See the upcoming issue at PNAS

Students

ALL CAMPUSES INVITED TO PARTICIPATE IN 3-ON-3 INDOOR SOCCER TOURNEY

On September 25, TAMSA invited all campuses to an intercampus battle royale between Temple-Round Rock and Bryan-College Station! This intercampus intramural competition was open to all medical students, faculty and staff, and the victorious Temple team received an (absurdly large) trophy as a symbol of their physical dominance.

The tourney was held at the Texas A&M Rec Center from 2-6 p.m. on September 25. Many thanks to Varghese Mathukutty (Temple-Round Rock), Colin Fuller (Bryan-College Station) and Robert Reid. See photos from this year's tourney and the team members in the next Dean's E-News.

2009 Intercampus Intramural Basketball champs from l to r: Drew Benac, John Wu, Ricky Savjani of the Temple Campus

THANKS TO NIS, GRAD STUDENT HEADED TO MD (MARYLAND, that is)

Chen Chen, a graduate student in Dr. James Samuel’s lab in the Department of Microbial and Molecular Pathogenesis, has been chosen to attend the fifth annual National Institutes of Health (NIH) National Graduate Student Research Festival to present his research. The Oct. 25-26 festival in Bethesda, MD, will introduce 200 advanced graduate students in the sciences to the NIH Intramural Research Program with the aim of recruiting them to do postdoctoral training at the NIH.

SCHI STUDENTS VOLUTEER IN TEMPLE

More than a dozen medical students, first-years through fourth-years, organized a Health Fest in Temple on August 14, 2010 as part of the group Student Community Health Initiative (SCHI). In addition to manning a bounce house and running an obstacle course, the students administered immunizations, performed screenings and
educated patients.

See the Texas A&M Health Science Center-College of Medincine photo album on Facebook

M3s VOLUNTEER AT HEALTH FAIR IN ROUND ROCK

Seven third-year medical students volunteered at a health fair sponsored by Sacred Heart Community Clinic in Round Rock on August 15, 2010.

They administered immunizations, took blood pressure and made sure the patients had a good time.

See the Texas A&M Health Science Center-College of Medincine photo album on Facebook

FORMER STUDENT DR. KEITH FRAZIER DIES AT 53

Keith Frazier, M.D. ‘91 passed away Wednesday, Aug. 25, 2010, at Hospice of East Texas in Tyler.

Frazier was born Jan. 19, 1957, in Norman, Okla., to Bob Gene and Maxine Meltabarger Frazier. He grew up in Texarkana, Texas, and then graduated from Stephen F. Austin State University in Nacogdoches in 1979. He graduated from the Texas A&M University College of Medicine (now the Texas A&M Health Science Center College of Medicine) in 1991 and completed his residency in internal medicine and pediatrics at the University of Arkansas for Medical Sciences in Little Rock, Ark. Frazier was affiliated with the Trinity Mother Frances Health System from 1995 to 2005 and with Hospice of East Texas for the past three years.

Frazier is survived by his wife, Terri Jernigan Frazier of Tyler; daughters, Rebekah, Amy and Hannah Frazier of Tyler; mother, Maxine Frazier; brothers, Bobby Frazier and wife Kim of Magnolia, and Phil Frazier; and sister, Yolanda Cook and husband Tommy of Texarkana, Texas.

Memorials in honor of Dr. Keith Frazier may be made to the Hospice of East Texas Foundation, 4111 University Blvd., Tyler, 75701.

From the Tyler Morning Telegraph

Administration

SHERWOOD TO SERVE AS VICE DEAN FOR GME, CME AND LIFE LONG LEARNING

T. Samuel (Sam) Shomaker, M.D., J.D., Dean of the Texas A&M Health Science Center College of Medicine, announces the appointment of Edward J. Sherwood, M.D. as the Vice Dean for Graduate Medical Education (GME), Continuing Medical Education (CME) and Life Long Learning. His full-time appointment became effective Sunday, August 1.

See the full article on TAMHSC-NEWS

HSC TO HOST RESEARCH SYMPOSIUM NOV. 11-12

Under the banner of “linking the Texas A&M Health Science Center from bench to bedside to community,” the HSC will host a research symposium Thursday-Friday, November 11-12, 2010 at the Henry D. Smith Building on the Brayton Fire Training Field in College Station.

Visit TAMHSC for more information.

LATEST NEWS FROM THE OFFICE OF GRADUATE STUDIES

Dr. Cynthia Meininger was appointed Director of Graduate Studies and the Associate Director of M.D./Ph.D. Program for the Temple Campus. Dr. David Huston was appointed Director of the M.D./Ph.D. program in Houston. Both will work with the college’s Office of Graduate Studies to guide graduate medical education in their
respective areas.

QEP TOPIC CHOSEN FOR THE HSC

When a thumbs-up from the Texas A&M Health Science Center (HSC) meets with a stamp of approval from the Southern Association of Colleges and Schools (SACS), true achievements in quality education will be recognized. And, that’s just what the HSC intends in preparing for re-accreditation.

See the full article at TAMHSC-NEWS

TECHNOTES FROM DR. JOE JILKA

Question: Does a poster at a scientific meeting count as “public disclosure” for purposes of patent law?

Answer: To the question as to whether a poster constitutes public disclosure — the answer is perhaps, under circumstances such as this if you have a poster or several posters that the public can readily access and see, the courts might regard that as a public disclosure. That would start the one-year time clock to file a US patent application. The real question about whether the disclosure at the meeting is a problem is whether it is an enabling disclosure (a disclosure that is sufficient for another to reproduce the invention).

For example, if a specific nucleotide sequence was essential in a method to identify a particular type of cancer and the disclosure was based around the screening method and data (but excluded the particular probe sequence) this would not be a publication of the invention as no one could replicate the invention without knowledge of the nucleotide sequence. Thus, there are ways of publishing data on posters and in lectures that do not disclose the invention.

Keep in mind that the grace period to file a patent application after disclosure of an invention is only available in very few countries (not at all in Europe and most of Asia). Therefore, if the invention is of high value and Europe and Asia are commercial targets for the invention, it is essential to file a disclosure with the Texas A&M Office of Commercialization (OTC) before disclosure as the grace period in the USA (and Australia) will not save the patent elsewhere. According to Europe and Asian patent laws, once the invention is disclosed, all patent rights to the invention are lost. The OTC will evaluate the disclosure and take the appropriate steps to protect the intellectual property if needed.

Another option would be to fill out an invention disclosure form and submit a disclosure to the OTC. Invention disclosure forms can be found on the OTC website. Generally the PI would explain what the problem is, how the prior art has failed to solve the problem, and how he or she will solve the problem. The OTC may decide to file a provisional patent application with the patent office before the session in order to establish a priority date.

Source: The Principal Investigators Association

Basic Science

HUMANITIES IN MEDICINE

On August 24, 2010, Dr. Nancy W. Dickey, President of the Texas A&M Health Science Center and Vice Chancellor for Health Affairs of the Texas A&M System, delivered the inaugural lecture for the College of Medicine Inter-Professional Heath Care Ethics course. The 10-week course, administered by the Department of Humanities, incorporates College of Nursing students, College of Pharmacy students and chaplain students from the Scott & White Healthcare Temple campus. Dr. Dickey’s lecture was also part of the annual John P. McGovern Humanities Seminar Series.

Medicine and Humanities Consultations 2010-2011

October 4, 2010: Dennis Bastron, M.D., presents “Physicians’ and Patients’ Exposure to Advertising: Informational Ignorance or Arrogance”
November 1, 2010: Lani Ackerman, M.D., presents “International Medicine and Medical Missions”
December 6, 2010: Alan Xenakis, MD, ScD, MPH, MS, moderates “Leadership in Health Care”
February 14, 2011: Marilyn Freimuth, Ph.D., presents “Behavioral Addictions: Choice or Disease”
March 28, 2011: Alma Golden, M.D., presents “Ethical Issues of Public Health on Family Reproductive Patterns”
May 2, 2011: Ed Eckenfelds, M.D., presents “Compassion and the Professions: The Skipjack Project”

For additional information, contact Tina M. Price at 979-845-0755 or price@medicine.tamhsc.edu. Consultations are held in The Longhorn Room, Stagecoach Inn, Salado, Texas from 1-6 p.m. We anticipate the approval of four hours physician Continuing Medical Education credit, Continuing Nurses Education credit and social worker
Continuing Education Units for each Consultation.

The 2010 John P. McGovern Lectureship and Seminar Series: Save the Date

Unless noted, all lectures in Lecture Hall II, Reynolds Medical Building

The 2010 John P. McGovern Lectureship in the Art and Science of Medicine

Ruth E. Berggren, M.D.
Director, Center for Medical Humanities and Ethics
University of Texas Health Science Center, San Antonio, Texas
“Allocation of Limited Resources in Healthcare”
October 19, 2010

The John P. McGovern Humanities Seminar Series

Rear Admiral Robert Kiser, M.D.
Commandant of the Medical Education & Training Campus
(METC)
Fort Sam Houston, San Antonio, Texas
“Physician Insecurity”
November 16, 2010 – Temple, MEC I
November 30, 2010, College Station, RMB LH I

Craig Blakely, Ph.D., M.P.H.
Dean, School of Rural Public Health
Texas A&M Health Science Center
“Disparities in Healthcare”
November 16, 2010

MICROBIAL & MOLECULAR PATHOGENESIS

Publications

Lentz, E.K., R.P. Cherla, V. Jaspers, B.R. Weeks, and V.L. Tesh. 2010. Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. Infection and Immunity Volume 78(9): 3689-3699.

Garcia-Contreras LD, Muttil P, Padilla D, Xu D, Liu J, Braunstein M, McMurray DN, Hickey AJ. Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity. AAPS J 12:338-347 (2010).

Presentations and Meetings:

Dr. McMurray traveled to Rockville, MD, from August 30-September 1, for the quarterly meeting of the Aeras Global TB Vaccine Foundation.

Dr. Helene Andrews-Polymenis traveled to Athens, Geogia, from August 5-7, to present an invited Burroughs Wellcome Seminar at the University of Georgia.

Dr. James Samuel, Dr. Laura Hendrix and Dr. Katja Mertens traveled to Stevenson, WA, to attend the American Society for Rickettsiology Meeting from July 31-August 3.

MOLECULAR & CELLULAR MEDICINE

Recent Publications

Bartosh, T.J., Ylöstalo, J.H., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., Lee, R.H., Choi, H., and Prockop, D.J. (2010). Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc. Natl. Acad. Sci. USA. 107(31): 13724-13729. 2010 Jul 19. [Epub ahead of print]

Liu, F., Dangaria, S., Andl,T., Zhang,Y., Wright, A. C., Damek-Poprawa, M., Piccolo, S., Nagy, A., Taketo, M.M., Diekwisch, T.G., Akintoye, S., and Millar, S.E. (2010) β-catenin initiates tooth neogenesis in adult rodent icisors. Journal of Dental Research. 89(9): 909-914. 2010, June [Epub ahead of print]

Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M.R., Samudio, I., Konopleva, M., Andreeff, M., and Safe, S. (2010). Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Mol. Pharmacol. 78(2): 226-236. 2010 May 20 [Epub ahead of print]

Jutooru, I., Chadalapaka, G., Sreevalsan, S., Lei, P., Barhoumi, R., Burghardt, R., and Safe, S. (2010). Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp. Cell Res. 316(13): 2174-2188. 2010 May 8 [Epub ahea d of print]

Safe, S. (2010). 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol. Sci. 117(1):1-3. 2010 Jul 22 [Epub ahead of print]

Jutooru, I., Chadalapaka, G., Lei, P., and Safe, S. (2010). Inhibitionof NF {kappa}B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation. J. Biol. Chem. 285(33): 25332-25344. 2010 June [Epub ahead of print].

Childs, E.W., Tharakan, B., Hunter, F.A., and Smythe, W.R. (2010) 17 [Beta]-Estradiol Mediated Protection against Vascular leak following Hemorrhagic Shock Role of Estrogen Receptors and Apoptotic Signaling. Shock. 34(3): 229-235. 2010 Feb 10. [Epub ahead of print]

Zhang, L., Zhang, B., Valdz, J.M., Wang, F., Ittmann, M., and Xin, L. (2010) Dicer Ablation Impairs Prostate Stem Cell Activity and Causes Prostate Atrophy. Stem Cell. 28:1260-1269.

Gao, S., Wu, H., Wang, F., and Wang, Z. (2010) Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77.Endocrinology.151:3941-3953.

Presentations

Dr. Kayla Bayless presented a talk entitled, “Recruitment and Modulation of Porcine Endothelial Progenitor Cells by Secreted Phosphoprotein 1 (SPP1, Osteopontin)” at the 43rd Annual Meeting of the Society for Study of Reproduction on August 1, 2010 in Milwaukee, Wisconsin. The study was co-authored by Drs. Gregory Johnson,
David Erikson and Robert Burghardt (Dept. of Veterinary Reproductive Biosciences), and Drs. Guoyao Wu and Fuller Bazer (Dept. of Animal Science).

Dr. J. Martin Scholtz presented a talk entitled “Charges and Consequences: Electrostatic Effects in Proteins” at the 24th Annual Symposium of the Protein Society Looking at Proteins: Expanding Perspectives and New Technologies on August 1-5, 2010 in San Diego, California.

Ryan Kramer from the Scholtz presented a poster entitled “ Towards a Molecular understanding of Protein Solubility” at the24th Annual Symposium of the Protein Society Looking at Proteins: Expanding Perspectives and New Technologies on August 1-5, 2010 in San Diego, California. The poster was co-authored by Saul Trevino, C. Nick Pace and J. Martin Scholtz.

Dr. Gregory Bix gave an invited oral presentation of his research entitled: “ECM and BBB Permeabilty: Perlecan Domain V Generation and Therapeutic Potential in Focal Cerebral Ischemia” on September 2nd at the 13th International Symposium of the Blood-Brain Barrier in Zurich, Switzerland.

Dr. Gregory Bix gave an invited research oral presentation entitled “Matrix Revolutions: Perlecan Domain V is a Novel Pro-angiogenic and Neuroprotective Therapy for Stroke and other Neuropathologies” on September 6th at the international headquarters of Sanofi-Aventis Pharmaceuticals in Paris, France.

Dr. Leyuan Liu was invited to give a lecture entitled “Roles of LRPPRC-C19ORF5-RASSF1A Complex in Autophagic Regulation and Tumor Suppression” on August 18, 2010 at the Department of Pharmacology, University of Texas Health Science Center at San Antonio in San Antonio, Texas.

Dr. Leyuan Liu was invited to give a lecture entitled “Roles of LRPPRC-C19ORF5-RASSF1A Complex in Autophagic Regulation and Tumor Suppression” on August 23, 2010 at the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine in Baltimore, Maryland

Grants

Dr. Gregory Bix received a $50,000 research grant from the Bob and Judith McNair Research Foundation. This represents the first grant awarded to a Texas A&M HSC faculty member by this foundation.

Dr. Kayla Bayless is a co-Investigator on a $599,885.00 grant awarded by the National Science Foundation Awarded to Dr. Alvin Yeh (Dept. of Biomedical Engineering) entitled “Engineering Angiogenesis by the Extracellular Matrix”.

NEUROSCIENCE & EXPERIMENTAL THERAPEUTICS

Publications

Zhuang, P, Shen, Y, and Chiou, GCY: Effects of flavones on the oxidation-induced injury of retinal pigment epithelium cells Internatl J. Ophthalmol. In press (2010)

Zhuang, P, Shen, Y and Chiou, GCY Effects of flavones on the ocular blood flow and formation of choroidal neovascularization Internatl J. Ophthalmol. 10:1455-1458 (2010)

Shen, Y, Zhuang, P and Chiou, GCY Effects of tetramethylpyrazine on RPE degeneration, choroidal blood flow, and oxidative stress of RPE cells. Internatl J. Ophthalmol. In press (2010)

Manuscripts accepted or in press

Samba Reddy, Ph.D.: Gangisetty O and Reddy DS. Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth factor-3 pathway. Neuroscience 2010 Jul 26. [Epub ahead of print] PMID: 20670676

Samba Reddy, Ph.D.: Reddy DS, Gangisetty O and Briyal S. Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis. Neuropharmacology 2010 (in press).

Mendell Rimer, Ph.D.: Rimer, M. (2010). Modulation of agrin-induced acetylcholine receptor clustering by extracellular regulated kinases 1 and 2 in cultured myotubes. Journal of Biological Chemistry. In press. PMID:20696763.

Invited Talks

On September 18, George Chiou, Ph.D., will present a seminar entitled, “Enjoy your golden life with good vision,” to the Golden Club of Houston.

Grants and Grants Reviewed

David Earnest, Ph.D.: NIH Grant Review - Reviewed 3 grants for NIH Special Emphasis Panel/Scientific Review Group ZAA1 JJ (01): Gut-Liver-Brain Interactions in Alcohol-Induced Pathogenesis

Gerald Frye, Ph.D.: NIH-NIAAA, 5 R01AA012386-07 CNS Development, BAGAARS and Vulnerability to Ethanol, G.D. Frye, 25%, D.W. DuBois, $133,650, 191,532 this year and the next; 8/1/08 – 7/31/2012

Samba Reddy, Ph.D.: NIH, 5r01NS051398-5 Progesterone receptors and seizure susceptibility, D. Samba Reddy, 50%, NA, $216,563 direct costs

Service

Ian Murray, Ph.D.: Associate Reviewer for the Journal of Alzheimer’s Disease

Ian Murray, Ph.D.: Interview for CNN Health, Expert advice concerning recent findings on Insulin resistance and Alzheimer’s disease. http://www.cnn.com/2010/HEALTH/08/25/diabetes.prone.alzheimers/index.html?hpt=Sbin
August 24, 2010

SYSTEMS BIOLOGY & TRANSLATIONAL MEDICINE

Presentations

Dr. Mariappan Muthuchamy presented a seminar entitled “Mechanotransduction in Cardiac Myocytes” at Life Cell, Inc., Chennai, India on June 24, 2010.

Publications

Gashev AA, Zawieja DC. Hydrodynamic regulation of lymphatic transport and the impact of aging. Pathophysiology. 2010 Sep;17(4):277-287. Epub 2010 Mar 11. PMID: 20226639

Professional Activities

Dr. Mariappan Muthuchamy participated in a group discussion on “Lymphatic Filariasis” with Dr. P. Kaliraj and his laboratory group at Anna University, Chennai, India on July 28, 2010.

Clinical Science

Latest News from the Center of Excellence for Research on Returning War Veterans

Dr. Marc Kruse received the NIAAA/NIDA Early Career Travel Award, 118th Annual Scientific Meeting of the American Psychological Association.

Dr. Sandra Morissette was awarded as the Central Texas Veterans Health Care System Outstanding Woman of the Year by the Federal Women’s Program celebrating Women’s Equality Day on August 26, 2010. The Federal Women’s Program Committee named four winners as Central Texas’ Outstanding Women of the Year and recognized all of the nominees during the Program which was held at the Temple Campus.

Dr. Sandra Morissette receives token of appreciation for improving the lives of veterans! A veteran and his three-year-old son came to the VISN 17 Center of Excellence for Research on Returning War Veterans to express their appreciation for the care the veteran has received. They presented to Dr. Morissette a small wall hanging saying, “Land of the Free, Because of the Brave.” The son said with a big smile, “My Daddy is better now.” The veteran stated that he is thankful for services he has received at CTVHCS and “whenever I fill out your research measures, I can see how much I have improved!” He was grateful for the research we are doing because he knew it was making a difference in his life and the lives of other veterans! This is a great example of how clinical and research services can work together to make a difference for our veterans.

DIVISION OF INVESTIGATIVE PATHOLOGY

Dr. Alexzander A. A. Asea

Presentations/meetings/workshops:

Asea, A., (2010) Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer. 1st Biennial Science of Global Prostate Cancer Disparities (GPC) Conference, August 27-29, 2010, Jacksonville, Florida

Educational Projects:

2010 Summer Research Program for the Division of Investigative Pathology, Department of Pathology, Scott & White Hospital and Clinic, Temple, Texas, July 12-August 14, 2010.

Notable Accomplishments:

USPTO Applicaton #: 20100186102: Methods and Compositions for Posttranscriptional Gene Silencing. USPTO Class: 800 13; USPTO Publishing Date: 07/22/2010

KWTX Channel 10 News. August 4, 2010. International Visitors to Scott & White Hospital

KWTX Channel 10 News. August 6, 2010. Medical Student Overcomes the Odds

Saudi Medical Students Get Inside Look at Local Research. Temple Daily Telegram. Vol. 103, No. 261. August 6,2010. Read NEWS

Conferences Attended:

1st Biennial Science of Global Prostate Cancer Disparities (GPC) Conference, August 27-29, 2010, Jacksonville, Florida

Dr. Punit Kaur

Abstracts Accepted/presented:

Kaur, P., and Asea, A. (2010) Radiation Therapy Induces Circulating Serum Hsp72 in Patients with Prostate Cancer” 1st Biennial Science of Global Prostate Cancer Disparities (GPC) Conference, August 27-29, 2010, Jacksonville, Florida

Lectures:

Lectures and practical classes during the 2010 Summer Research Program for the Division of Investigative Pathology, Department of Pathology, Scott & White Hospital and Clinic, Temple, Texas, July 12-August 14, 2010. Subjects included “Tissue Cultures Techniques” and “Proteomics”

Awards:

Award for “Excellence in Lectures and Practicals” during the Summer Research Program, Division of Investigative Pathology, Department of Pathology, Scott & White Hospital and Clinic, July 12-August 14, 2010

Conferences Attended:

1st Biennial Science of Global Prostate Cancer Disparities (GPC) Conference, August 27-29, 2010, Jacksonville, Florida

Dr. Nagaraja Ganachari-Mallappa

Manuscripts Accepted/presented:

Nagaraja GM, Kaur P, Bausero MA, Multhoff G, and Asea A. Hsp25 is a repressor of PA28α and prohibitin: role in tumor growth and antigen presentation. Molecular Therapy, (Under revision).

Research Projects:

Development of Anti-Tumor Therapy for Breast Cancer, Effects of Hsp25 silencing on Pancreatic cancer and understanding the signaling mechanisms. To identify novel Hsp25 interacting proteins, yeast two hybrid screening study has been initiated and research work is under progress.

Lectures:

Educational Projects:

Lectures and practical classes during the summer research program students on cDNA preparation, RNA isolation from cells, 2D gel electrophoresis sample preparation, IFE focusing and 2-dimension SDS-PAGE gel electrophoresis, Real- time PCR assay set up and data analysis, RT-PCR analysis and the PCR products separation on agarose gel electrophoresis, introduction of plasmid DNA into pancreatic tumor cells and the procedure called transfection and monitoring the transfection by using green fluorescent protein as a reporter gene.

Awards:

Dr. Paola Rosas

Research Projects:

1. Heat shock treatment potential in Type 2 Diabetes Mellitus
2. Levels of heat shock proteins 27, 60, 70 and 90 in the pancreas of type 2 diabetic patients: cellular stress response in type 2 Diabetes Mellitus

Conferences Attended:

1. qPCR innovations and workflow. August 18, 2010
2. 2nd Symposium for the Center for Cell Death and Differentiation. August 19, 2010

Princess Bempong

Presentations/meetings/workshops:

Princess Bempong: Expressions of Heat Shock Proteins in Amniotic Fluids, August 13, 2010 New Technologies and qPCR Presentation, August 18, 2010

Notable Accomlishments:

KWTX Channel 10 News. August 6, 2010. Medical Student Overcomes the Odds

INTERNAL MEDICINE

Manuscripts Accepted/In press/In Review

Hematology/Oncology – Manuscripts

1. Agrawal V, Frankel AE. 14G2a anti-GD2 cross reactivity with the CD166 antigen. J Immuno, in Press.
2. Cable CT, Ahluwalia R,* Mirkes C, Colbert CY. A case of disseminated intravascular coagulation associated with a prosthetic heart valve. Amer J of Med Sci. Accepted July 2010. In revision. (*Medical student)

Medical Education – UME/GME – Manuscripts

Cardiology Fellowship Program
1. Blackwell J, Cable C, Smith D, Boethel C, Puschett JB. A 41-Year-Old-Man with Massive Splenomegaly, Fevers, and Night Sweats. Am J Med Sci. 2010. In press. July 2010. Jeff Blackwell, MD is a cardiology fellow.

DOM Office of Medical Education, Evaluation & Research Development
2. Colbert CY, Ogden PE, Ownby AR, Bowe C. Systems-Based Practice in Graduate Medical Education: Systems Thinking as a Foundational Construct. Teaching and Learning in Medicine. Accepted. In revision July 2010.

Nephrology - Manuscripts

1. EE Agunanne, MN Uddin, D Horvat, JB Puschett. Contribution of Angiogenic Factors in a Rat Model of Preeclampsia, Am J Nephrol 2010 (In Press).

Nephrology Lab-Manuscripts

1. Chiasson VL, Jones KA, Mahajan A, Young KJ, Mitchell BM. Endothelial FK506 binding protein 12 deficiency causes renal arteriole hyalinosis. Am J Physiol Renal Physiol 2010;(in press).
2. Chiasson VL, Munshi N, Young KJ, Mitchell BM. Pin1 deficiency increases endothelial nitric oxide synthase serine 116 phosphorylation, endothelial dysfunction, and blood pressure. Circ Res 2010;(in review).

Abstracts – Accepted/Presented

Cardiology-Molecular - Abstracts

1. Singh VP, Colata F, Baker KM, Kumar R. Involvement of Protein O-Glycosylation and Transcription Factors Sp1 and p53 in Hyperglycemia-Induced Activation of the Renin-Angiotensin System in Cardiac Myocytes. 70th Scientific Sessions, American Diabetes Association, 2010, Orlando, FL. Diabetes Vol. 59 Suppl. 1: A437, 2010.
2. Guleria RS, Choudhary R, Tanaka T, Baker KM, Pan J. Decreased Expression of Retinoid Receptor Is Involved in Diabetes Induced Cardiac Remodeling. 70th Scientific Sessions, American Diabetes Association, 2010, Orlando, FL. Diabetes Vol. 59 Suppl. 1: A122, 2010.
3. Guleria RS, Tanaka T, Baker KM, Pan J. Targeted Activation of Retinoid Receptor Mediated Signaling Protects Cardiomyocytes from Free Fatty Acid-Induced Apoptosis. 70th Scientific Sessions, American Diabetes Association, 2010, Orlando, FL. Diabetes Vol. 59 Suppl. 1: A531, 2010. 4. Honey Golden’s abstract entitled “Unraveling the Phospholamban signaling Network in anthrax-Induced Cardiac Dysfunction” was accepted for poster presentation at the 2010 AHA Basic Cardiovascular Sciences Conference in Rancho Mirage, CA, July 2010. (Honey Golden (presenter), Linley E. Watson, Deepika Gollapudi, Nimrit Goraya, Swagoto Mukhopadhyay, Marcelo Ribeiro, Donald Foster, and David E. Dostal)

Medical Education – UME/GME - Abstracts

IM Residency Program
1. Vincent Scott, MD; Christopher D Spradley, MD FCCP. “Extranodal Rosai-Dorfman Disease Presenting as Hemoptysis: A Case Report” CHEST 2010. Accepted July 2010. Podium presentation. Vincent Scott, MD is an Internal Medicine resident.

IM Residency Program & GI Fellowship Program
2. Anu Duddempudi, Jonathan Ramirez, Moazzam Sana, Dawn Sears. “Rate of Pre-Chemotherapy Screening for Hep C in patients with lymphoma or metastatic colon cancer”- Abstract accepted July 2010 for poster presentation at the American College of Gastroenterology Conference, San Antonio, TX, Oct. 15-20, 2010. Dr. Duddempudi is a GI fellow and Drs. Ramirez and Sana are IM residents. .

GI Fellowship Program
3. Tim Miller, MD, Dawn Sears, MD, Maria Blazo, MD. “Chronic Liver Failure and Progressive Neurologic Decline Due to Mitochondrial Depletion.” Abstract accepted July 2010 for poster presentation at the American College of Gastroenterology Conference, San Antonio, TX, Oct. 15-20, 2010. Tim Miller, MD is a GI fellow.

4. Geoffrey Fillmore DO, Richard Erickson MD, Juhee Song PhD, Mark Jeffries DO. “Probability of Choledocholithiasis As Determined By Rate of Change of Liver Tests” Abstract accepted July 2010 for poster presentation at the American College of Gastroenterology Conference, San Antonio, TX, Oct. 15-20, 2010. Geoffrey Fillmore, DO is a GI fellow.

Pulmonary Fellowship Program
5. M Heather Henderson, MD; Christopher D Spradley, MD FCCP. “Pulmonary Hypertension Registry: A Local Experience Compared to National Baseline Characteristics” CHEST 2010 conference. Abstract accepted for poster presentation July 2010. Heather Henderson, MD is a pulmonary fellow.

Book Chapters

Medical Education – UME/GME

1. Myers JD, Cable C, McNeal T, Skeen S, Mirkes C, Colbert CY. Mentoring Residents Pursuing Careers in General Internal Medicine. In “The Toolkit Series: A Textbook for Today’s Chief Medical Resident, 19th Edition. Washington, DC: Association of Program Directors in Internal Medicine. Invited June 2010; submitted July 2010.
(Editor: Bud Williams). Dr. Skeen was a Chief Resident at the time.

E-Publications

Gastroenterology

1. Sears D. “Fatty Liver Disease.” Gastroenterology. Emedicine chapter. emedicine from WebMed.

Research Projects

Cardiology-Molecular – Research Projects

1. Baker K & Rajesh Kumar, Ph.D. - Intracellular RAS in Development of Diabetic Cardiomyopathy–Novartis
2. Baker K. - Novel Aspects of the Cardiac Renin Angiotensin System–National Institutes of Health
3. Baker K. - Role of Retinoid Mediated Signaling in Diabetes and Cardiac Remodeling–National Institutes of Health
4. Baker- Jing Pan, M.D. Ph.D. - Molecular Mechanisms of Osteoporosis in Diabetes Mellitus – Scott & White Research Vision Award

Endocrinology- Research Projects

1. Reddy-Working on assessment of resident knowledge regarding diet/exercise and counseling

Nephrology – Research Projects

1. Puschett-Marinobufagenin increases vascular permeability.
2. Puschett- Development of a rapid ELISA assay for measurement of marinobufagenin.
3. Puschett- Genetic etiology of excessive volume expansion in preeclampsia.
4. Puschett- Resibufogenin as a therapeutic in volume expansion-mediated hypertension.
5. Puschett- Investigation of Salt Handling in Preeclamptic and Normal Post- partum Patients.
6. Puschett-Investigation of levels of marinobufagenin in preeclamptic and normotensive pregnant patients.
7. Puschett-Investigation of levels of marinobufagenin in hypertensive and normotensive patients
8. Puschett-The determination of marinobufogenin levels in patients with acute respiratory distress syndrome.

Nephrology Lab-Research Projects

1. Mitchell- Summer Medical Student Research Program
Medical Student: Laura Weaver

Presentations

Cardiology-Molecular - Presentation

1. Baker- Intracellular Renin-Angiotensin System: A New Paradigm, Division of Endocrinology, Department of Medicine, Scott & White, Temple, Texas, 15 June, 2010.

Endocrinology - Presentations

1. National: New developments in Osteoporosis, Endo causes of chronic fatigue, Therapy of Lipid disorders, Overview of Diabetes
2. Regional: Update in obesity and diabetes, Endo board review, osteoporosis

Gastroenterology- Presentations

Regional
1. Sears D: MKSAP Board Review and GI pearls. South Padre Review for Internal Medicine, 7/2010.
2. Sears D: Adventures in Liverland, South Padre Review for Internal Medicine, 7/2010.
3. Sears D: GERD: To Scope or Not to Scope, South Padre Review for Internal Medicine.

Medical Education (UME/GME)- Presentations

Regional
1. McNeal, T. Invited lecturer for the Scott & White Internal Medicine Review for Primary Care Providers in South Padre, Texas. Top 10 POEMs. July 22, 2010

Nephrology- Presentations

National
1. Concepcion-“ESAs after TREAT, CHOIR and CREATE: Where are we?”, Renal Physicians Association 2010 Advanced Practitioner Annual Conference, St Louis MO, July 22, 2010.
Regional
2. Chaffer- “Newly Elevated Creatinine in the Outpatient Clinic”, 29th Annual Internal Medicine Review for the Primary Care Provider, South Padre Island, Texas, July 22, 2010.
3. Chaffer-“Nephrology Case Style Questions”, 29th Annual Internal Medicine Review for the Primary Care Provider, South Padre Island, Texas, July 22, 2010.

Posters/Exhibits

Gastroenterolgy Lab- Poster/Exhibits

1. H Francis, J Venter, T Francis, P Onori, S Kopriva, S DeMorrow, W Butler, M White, A Franchitto, F Meng, E Gaudio, and G Alpini. While Ca2+-dependent small cholangiocyte proliferation is mediated by the activation of H1 histamine receptors (H1HR), CAMP-dependent large cholangiocyte growth depends on the activation of H2HR. Accepted for poster presentation at American Association for the Studies of Liver Diseases, Boston, 2010.

2. S Glaser, P Onori, j Venter, M White, S Kopriva, Y Ueno, F Meng, A Franchitto, E Gaudio, R Mancinelli, and G Alpini. Neurogenic differentiation 1 (NeuroD1) is required for the de novo expression of secretin and the neuroendocrine differentiation of small cholangiocytes during the damage of large cholangiocytes. Accepted for
poster presentation at American Association for the Studies of Liver Diseases, Boston, 2010.

3. A Renzi, P Onori, S DeMorrow, Y Han, R Mancinelli, S Glaser, H Francis, J Venter, S Kopriva, A Franchitto, W Butler, M White, Y Ueno, F Meng, E Gaudio, and G Alpini. Increased expression of serotonin N-acetyltransferase (AANAT, the key enzyme responsible for the synthesis of melatonin) in cholangiocytes causes inhibition of biliary proliferation: evidence for a novel autocrine loop regulating biliary hyperplasia. Accepted for poster presentation at American Association for the Studies of Liver Diseases, Boston, 2010.

4. A Holterman, K Wang, S Glaser, Y Uneo, H Chen, and G Alpini. Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts. Accepted for poster presentation at American Association for the Studies of Liver Diseases, Boston, 2010.

5. L L Hubble, H Francis, S DeMorrow, Y Han, S Glaser, J Venter, Li Huang, S Kopriva, Y Ueno, S Priester, G Alpini, and F Meng. TGF- mediated colony-stimulating factors regulation of cholangiocyte remodeling during hepatic regeneration. Accepted for poster presentation at American Association for the Studies of Liver Diseases,
Boston, 2010.

6. F Meng, S Glaser, H Francis, S DeMorrow, T Lairmore, L Wong, M W Majdoub, J D Passarini, Jay Sharma, Y Han, Md. K Munshi, L L Hubble, J Ramirez, S Priester, and G Alpini. Epigenetic regulation of CD133 and chemosensitivity in human gallbladder cancer stem cells. Accepted for oral presentation at American Association for
the Studies of Liver Diseases, Boston, 2010.

7. A Omenetti, LL Bass, R Anders, MG Clemente, H Francis, CD Guy, SS Choi, G Alpini, K Schwarz, P Whitington, and AM Diehl. Hedgehog pathway drives the acquisition of mesenchymal markers in ductular cells of patients with biliary atresia. Accepted for oral presentation at American Association for the Studies of Liver Diseases,
Boston, 2010.

8. Y Han, Q Jing, H Francis, S Glaser, A Stokes, S Priester, L L Hubble, C-G Liu, J Venter, G Alpini, H Tsukamoto, and F Meng. Emerging roles of microRNAs in the control of apoptosis and transformation in hepatobiliary cells during alcoholic liver injury. Accepted for oral presentation at American Association for the Studies of Liver Diseases, Boston, 2010.

Molecular Cardiology – Poster/Exhibit

1. Honey Golden received 1st place in the Basic Sciences Poster Competition at the S&W Internal Medicine Research Day in Temple, May 14, 2010. The title of the poster was “Role of Phospholamban Dysregulation in Anthrax Lethal Toxin-Induced Heart Failure”. (Honey Golden (presenter), Linley E. Watson, Deepika Gollapudi,
Nimrit Goraya, Swagoto Mukhopadhyay, Marcelo Ribeiro, Donald Foster, and David E. Dostal

2. Linley E. Watson, Deepika Gollapudi, Nimrit Goraya, Swagoto Mukhopadhyay, Marcelo Ribeiro, Donald Foster, and David E. Dostal. “Unraveling the Phospholamban signaling Network in anthrax-Induced Cardiac Dysfunction.” Abstract accepted for poster presentation at the 2010 AHA Basic Cardiovascular Sciences Conference
in Rancho Mirage, CA, July 2010. (Honey Golden - presenter)

Lectures

Endocrinology- Lecture

1. Reddy D- Resident lecture on Endocrine Emergencies July 27

Gastroenterology – Lectures

1. Sears D: Workup of Abnormal LFT’s. Scott & White, GI fellows and staff.

Gastroenterolgy Lab-Lectures

1. Alpini- Talk at R&D meeting, VA, Temple, TX, July 27, 2010. Overview on DDRC activity.

Hospital Medicine-Lectures

1. Vohra-Inpatient Lecture Series (Syncope) 7/6/2010
2. Varghees- Inpatient Lecture Series (DKA) 7/7/2010
3. Vohra- Inpatient Lecture Series (Hyponetremia) 7/12/2010
4. Chang- Inpatient Lecture Series (Acute Renal Failure) 7/13/2010
5. Alger- Inpatient Medicine Series (Dyspnea) 7/19/2010

Nephrology – Lectures

1. Chaffer-“Evaluation of AKI”, Nephrology Core Lecture, Scott & White Temple, July 12, 2010. (Fellows,senior staff)
2. Chaffer-“HTN Emergencies”, Nephrology Core Lecture, Scott & White Temple, July 16, 2010. (Fellows, senior staff, nurse practitioner)
3. Chaffer-“Anemia Management”, Nephrology Core Lecture, Scott & White Temple, July 28, 2010. (Fellows, senior staff, physician assistant)
4. Duke-“Ca-PO4 Rx with CKD”, Nephrology Core Lecture, Scott & White Temple, July 21, 2010. (fellows, senior staff, nurse practitioner, physician assistant, renal dietitians)
5. Duke-“Hyponatremia Evaluation / Therapy”, Nephrology Core Lecture, Scott & White Temple, July 27, 2010. (fellows, senior staff, nurse practitioner).
6. Concepcion-“Principles of Dialysis, Part 1”, Nephrology Core Lecture, Scott & White Temple, July 1, 2010. (fellows, senior staff, physician assistant)
7. Concepcion-“Principles of Dialysis, Part 2”, Nephrology Core Lecture, Scott & White Temple, July 2, 2010. (fellows & senior staff)
8. Concepcion-“Principles of Dialysis, Part 3”, Nephrology Core Lecture, Scott & White Temple, July 6, 2010. (fellows, senior staff, nurse practitioner)
9. Concepcion-“Principles of Dialysis, Part 4”, Nephrology Core Lecture, Scott & White Temple, July 7, 2010. (fellows, senior staff, physician assistant)
10. Concepcion-“Principles of Dialysis, Part 5”, Nephrology Core Lecture, Scott & White Temple, July 8, 2010. (fellows, senior staff, physician assistant, nurse practitioner)
11. Concepcion-“Principles of Dialysis, Part 6”, Nephrology Core Lecture, Scott & White Temple, July 9, 2010. (fellows, senior staff, nurse practitioner)
12. Concepcion-“Hyperkalemia”, Nephrology Core Lecture, Scott & White Temple, July 13, 2010. (fellows)
13. Narayanan-“Transplant 101, Part 1”, Nephrology Core Lecture / Transplant Grand Rounds, Scott & White Temple, July 22, 2010. (fellows, senior staff, nurse practitioner, physician assistant, nurses)
14. Narayanan-“Transplant 101, Part 2”, Nephrology Core Lecture / Transplant Grand Rounds, Scott & White Temple, July 29, 2010. (fellows, senior staff, nurses, social worker)

Pulmonary-Lectures

1. Spradley-“Practical Pulmonary for the Outpatient Setting” & “Critical Care Conundrums” for Scott & White CME Internal Medicine at South Padre Island – Internal Medicine Practitioners
2. Spradley-“Short Winded Essentials: Pulmonary Hypertension
3. Spradley--Pulmonary Fellows (local)
4. Yau- Mechanical ventilation Basics ( Powerpoint presentation) ( Annual Respiratory therapist symposium) 7/16

Articles Reviewed – Peer – Reviewed Journals

Nephrology- Articles Reviewed

1. Mitchell-1 – Hypertension
2. Mitchell-1 – American Journal of Transplantation

Grants

Cardiology- Grants

1. Nair- Investigator Initiated grant from Novartis start date Jan 2011 on Effect of RAAS inhibition on diastolic dysfunction PI Nandini Nair MD,PhD

Gastroenterology – Grants Funded

1. Sears D (PI). S&W Research Advancement Award: “Colonoscopy And Screening for Hepatitis:CASH” - Offer babyboomers the chance to be simultaneously screened for viral hepatitis at the time of IV placement prior to colonoscopy. ($31,500 x 2 years)

Geriatrics & Medical Education - Grants Funded

1. Scott & White Research Foundation & Scott & White Simulation Grant Program “Simulation Training and Assessment for Patient Engagement in Healthcare” Wehbe-Janek, H. (PI). Co-investigators: Hochhalter A, Colbert CY. ($43,662)

Nephrology-Grants Funded

1. Mitchell- Start Date: 8/1/10
    PI: Brett Mitchell
    Source: S&W Research Advancement Award
    Amount: $50,000 Duration: 1-2 years

Pulmonary-Grants Funded

1. Spradley C (PI).“ICU Videos to Engage Families in Critical Care”
    Source: Scott & White R&E
    Amount: $40,000.00
    Duration: 2 years
    Fellow: M Heather Henderson
    Residents: Vincent Scott, Brian Barnett

Notable Accomplishments: Faculty News, Appointments, Nominations

Cardiology- Notable Accomplishments

1. Nair- Elected as fellow of the American College of Cardiology
2. Nair- Elected as fellow of the American College of Physicians

Cardiology-Molecular- Notable Accomplishments

1. Gupta- Serves on American Heart Association National Reviewer Panel

Gastroenterology - Notable Accomplishments

1. Sears D - Medical Director of Wellness

Nephrology –Notable Accomplishments

1. Narayanan- Appointment as Kidney Councilor for the 2010-2011 Texas Transplantation Society’s Executive Committee

INTERNAL MEDICINE RESEARCH

Papers

S Glaser, I P Lam, A Franchitto, E Gaudio, P Onori, B K Cho, S Kopriva, J Venter, M White, Y Ueno, D Dostal, G Carpino, R Mancinelli, V Chiasson, S DeMorrow, H Francis, and G Alpini. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Hepatology 52:204-214, 2010.

S Glaser, M Wang, Y Ueno, J Venter, Chen H, G Alpini, and A Holterman. Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large ducts. Am J Physiol Gastrointest Liver Physiol. 2010 Jun 24. [Epub ahead of print]. PMID: 20576918 [PubMed - as supplied by publisher].

H Francis, G Alpini, and S DeMorrow. Recent advances in the regulation of cholangiocarcinoma growth. Am J Physiol 299:G1-9, 2010.

Academic Medicine

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