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James Littlejohn

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Entry Year: 2003
Graduation Year: 2010
Email Address: jelittlejohn@medicine.tamhsc.edu
Undergraduate: University of California at Berkeley, B.A. Molecular and Cellular Biology
Research Interests: Molecular Therapeutics and Translational Biology
Thesis: "BCL-XL Mediated Pathways of Programmed Cell Death in Colon AdenoCarcinoma"
Laboratory: Dr. Roy Smythe, Department of Surgery

Abstracts and Presentations

  • Littlejohn, J.E., Y. Baily, C. Rodarte, L. Zhang, X. Cao, and W.R. Smythe.  "Inhibition of Bcl2-xL engenders apoptosis in colorectal cancer". Presented at Texas A&M Cardiovascular Research Institute Research Retreat, 2006. 
  • Littlejohn, J.E., S. Miller, M. Ozvaran, L. Zhang, C. Rodarte,and W.R. Smythe.  "Antisense therapy with cis-platnin extends survival in SCID mice with established mesothelioma xenografts."  Sidney Kimball Cancer Center Meeting, Coronado, CA, 2007.
  • Littlejohn, J.E., X. Cao, C. Rodarte, L. Zhang, and W.R. Smythe.  "Autophagy in response to metabolic stress is implicated in SAHA resistance within malignant pleural mesothilioma." 44th Annual Society of Thoracic Surgeons Meeting, Fort Lauderdale, FL, 2008.
  • Littlejohn, J.E.,  X. Cao, C. Rodarte, L. Zhang, P. Rasco, J. Daniel, and W.R. Smythe.   "HGF signaling and its influence on Bcl-xL dysregulation of malignant pleural mesothilioma. 3rd Annual Academic Surgical Congress, Huntington Beach, CA, 2008.
  • Littlejohn, J.E., D. Jupiter, V.O. Speights, X. Cao, L. Zhang, H.T. Papaconstantinou, H.T., and W.R. Smythe.   “Implications of Beclin-1, mediator of autophagy, in the clinical progression of colon cancer.”  Texas A&M College of Medicine, 3rd Annual Department of Surgery Research Day, 2008.
  • Littlejohn, J.E., X. Cao,  L. Zhang, and W.R. Smythe.  “Differential Expression of Beclin-1, mediator of autophagy, during clinical progression of colon cancer.”  American College of Surgeons Surgical Forum, 94th Annual Clinical Congress, 2008.
  • Littlejohn, J.E., D. Jupiter, V.O. Speights, X. Cao, L. Zhang, H.T. Papaconstantinou, H.T., and W.R. Smythe.   “Expression of Beclin-1 and Bcl-xL Correlate with Colon Cancer Carcinogenesis.”  4th SUS/AAS Academic Surgical Congress, 2009.
  • Littlejohn, J.E., D. Jupiter, X. Cao, L. Zhang, M. Shabahang, M., and W.R. Smythe. “ BNIP3L (Nix) Expression in Colon Cancer.”  American Society of Clinical Oncology, Annual Meeting, 2009.

 Publications

  • Rigden, D.J., J.E. Littlejohn,, K. Henderson, and M.J. Jedrzejas. "Structures of phosphate and trivanadate complexes of Bacillus stearothermophilus phosphatase PhoE: structural and functional analysis in the cofactor-dependant phosphoglycerate mutase superfamily." J. Mol. Biol. 325:411-420, 2003.
  • Rigden, D.J., E. Lamani, L.V. Mello, J.E. Littlejohn, M.J. Jedrzejas. "Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling." J. Mol. Biol. 328:909-920, 2003.
  • Kolberg J., A. Aase, G. Rodal, J.E. Littlejohn, and M.J. Jedrzejas. "Epitope mapping of pneumococcal surface protein A of strain Rx1 using monoclonal antibodies and molecular structure modeling." FEMS Immunol Med Microbiol. 39:265-273, 2003.
  • Bumbaca D., J.E. Littlejohn, H. Nayakanti, D.J. Rigden, M.Y. Galperin, and M.J. Jedrzejas.  "Sequence analysis and characterization of a novel fibronectin-binding repeat domain fro the surface of Streptococcus pneumoniae." OMICS. 8:341-356, 2004.
  • Rigden, D.J.,  J.E. Littlejohn, H.V. Joshi, B.L  deGroot, and M.J. Jedrzejas. "Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: Insights into enzyme flexibility and underlying molecular mechanism of action." J. Mol. Biol. 358: 1165-1178, 2006.
  • Bumbaca D,  J.E. Littlejohn, H. Nayakanti,  A.H. Lucas, D.J. Rigden, M.Y. Galperin, and M.J. Jedrzejas. Genome based identification and characterization of a putative mucin-binding protein from the surface of  Streptococcus pneumoniae. Proteins-Structure Function and Bioinformatics 66 (3): 547-558, 2007
  • Nukui M., L.V Mello, J.E. Littlejohn, B. Setlow, P. Setlow, K. Kim, T. Leighton, and M.J. Jedrzejas. Structure and molecular mechanism of Bacillus anthrasis cofactor-independent phosphoglycerate mutase: A crucial enzyme for spores and growing cells of Bacillus species. Biophysical Journal 92 (3): 977-988, 2007
  • Cao, X., C. Rodarte, L. Zhang, C.D. Morgan, J. Littlejohn, and W.R. Smythe.  Bcl2/bcl-x(L) Inhibitor Engenders Apoptosis and Increases Chemosensitivity in Mesothelioma. Cancer Biol Ther 6:246-252, 2007.
  • Littlejohn, J.E., X. Cao, S.D. Miller, M.K. Ozvaran, D. Jupiter, L. Zhang, C. Rodarte, and W.R. Smythe. "Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts." Int. J. Cancer 123:202-8, 2008.

Awards

  • AMA Foundation: Physicans of Tomorrow Texas A&M HSC COM Candidate for Scholarship, 2006.