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Gavin Roddy

Gavin Roddy

Entry Year: 2007
Currently: M4
Email Address: gwroddy@medicine.tamhsc.edu
Undergraduate: Texas A&M University, B.S. Biomedical Science
Laboratory:  Dr. Darwin Prockop, MD, PhD
Research Interests: Therapeutic applications adult stem/progenitor cells (mesenchymal stem cells; MSCs)
Dissertation: "Adult stem/progenitor cells and their secreted proteins for the treatment of ocular disease"

Abstracts and Presentations

  • Roddy GW, LaVail MM, Oh JY, Matthes MT, Yasumura D, Rosa RH, Prockop DJ.  Intravitreal administration of adult stem/progenitor cells and their secreted proteins delays retinal degeneration by decreasing apoptosis in two rat models.  Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, FL, May 2011
  • Oh JY, Roddy GW, Choi HS, Lee RH, Rosa RH, Prockop DJ. Cornea as a model system for inflammatory responses to sterile injury. Small heat shock protein (HSPB4) synthesized by keratocytes triggers the major wave of neutrophil infiltration by activating macrophages. Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, FL, May 2011  
  • Roddy, G.W., J.Y. Oh, H.S. Choi, R.H. Lee, U. Krause, R.H. Rosa, and D.J. Prockop.  Adult stem/progenitor cells (MSCs) and their secreted proteins reduce inflammation in the cornea following chemical injury.  Abstract accepted for the National MD/PhD Student Conference, Keystone CO.  July 2010.
  • Oh J.Y., G.W. Roddy, R.H. Lee, K. Claypool, and D.J. Prockop.  The anti-inflammatory and the anti-apoptotic proteins from adult stem/progenitor cells (MSCs) protect corneal epithelial progenitors from injury by preventing apoptosis and suppressing inflammation.  International Society for Stem Cell Research (ISSCR).  San Francisco, CA.  June 2010.
  • Rosa, R.H., G.W. Roddy , U. Krause, and D.J. Prockop.  Feasibility Study on Intravitreal and Subretinal Delivery of Adult Stem/Progenitor Cells (MSCs) for Retinal Repair.  The Association for Research in Vision and Ophthalmology (ARVO).  Fort Lauderdale, FL.  May 2010.
  • Oh J.Y., G.W. Roddy, H.S. Choi, R.H. Lee, K. Claypool, and D.J. Prockop. Adult stem/progenitor cell-derived factors protect corneal epithelial progenitors by promoting proliferation and preventing apoptosis.  The Association for Research in Vision and Ophthalmology (ARVO).  Fort Lauderdale, FL.  May 2010.  
  • Roddy, G.W, J.Y. Oh, H.S. Choi, R.H. Lee, U. Krause, R.H. Rosa, and D.J. Prockop.  The anti-inflammatory protein TSG-6, produced by activated adult stem/progenitor cells (MSCs), reduces inflammation in the cornea following chemical injury.  GSBS Student Research Symposium, College Station TX.  April 2010.
  • Roddy, G.W. and A.C. Lekven.  What the Zebrafish has to Tell us About Wnt6.  The Fourth Biennial Texas and Southern Plains Zebrafish Conference, College Station, TX. June 2007.
  • Roddy, G.W. and K.J. Bayless.  Abnormal Enzymatic Turnover of TIMP-3 in Sorsby’s Fundus Dystrophy and Macular Degeneration.  Texas A&M University Student Research Week, College Station, TX. March 2007.
  • Shivapurkar, N., V. Stastny, G.W. Roddy, H.F. Liu, J.D. Minna, and A.F. Gazdar.  Development of quantitative PCR assays for methylation of novel tumor suppressor genes and their application as a biomarker assay for multiple types of cancers. American Association of Cancer Research (AACR), Las Angeles, California. April 200
  • Roddy, G.W., K.K. Svoboda, R. West, M. Roberts, S. Senkayi, and E.K. Harrington. Proliferation Protein Ki-67 is Increased in PTH Exposed Primary Cartilage. American Academy of Dental Research (AADR), Orlando, Florida.  April 2006
  • R. West, E.K. Harrington, G.W. Roddy, M. Patel, and K.K. Svoboda.  Activation of the PTH/PTHrP Receptor Increases Cyclin-D1 mRNA Levels. American Academy of Dental Research (AADR), Orlando, Florida.  April 2006.

Publications

  • Oh JY, Lee RH, Yu JM, Ko JH, Lee HJ, Ko AY, Roddy GW, Prockop DJ. Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response.  Mol Ther. 2012 Aug 28. doi: 10.1038/mt.2012.165. [Epub ahead of print]
  • Oh JY, Choi H, Lee RH, Roddy GW, Ylöstalo JH, Wawrousek E, Prockop DJ.  Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea.  EMBO Mol Med. 2012 Feb 22. [Epub ahead of print]. PMID: 22359280.
  • Roddy GW, Rosa RH, Oh JY, Ylostalo JH, Bartosh TJ, Choi H, Lee RH, Yasumura D, Ahern K, Nielsen G, Matthes MT, Lavail MM, Prockop DJ.  Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration.  Mol Ther. 2012 Jan 31. [Epub ahead of print]. PMID: 22294148.
  • Roddy GW, Oh JY, Lee RH, Bartosh TJ, Ylöstalo J, Coble K, Rosa RH, Prockop DJ.  Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6.  Stem Cells. 2011 Oct;29(10):1572-9.  PMID: 21837654.
  • Oh JY, Roddy GW, Choi H, Lee RH, Ylöstalo JH, Rosa RH, Prockop DJ.  Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury.  Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16875-80. Epub 2010 Sep 13. PMID: 20837529.
  • Harrington EK, Roddy GW, West R, Svoboda KK.  Parathyroid hormone/parathyroid hormone-related peptide modulates growth of avian sternal cartilage via chondrocytic proliferation.  Anat Rec (Hoboken). 2007 Feb;290(2):155-67. PMID: 17441208.

Awards

  • 2012    Texas A&M Health Science Center, President’s Scholarship Nominee
  • 2011    Association for Research in Vision and Ophthalmology, Foundation for Eye Research/Retina Research Foundation/Joseph M. and Eula C. Lawrence Travel Grant Recipient
  • 2010    First Place, Oral Presentation, Texas A&M HSC Student Research Symposium, College Station, TX