Darwin Prockop is a Professor of Molecular and Cellular Medicine and the Stearman Chair in Genomic Medicine. He is also the Director of the Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White in Temple, Texas. He received his A.B. in Philosophy from Haverford College in 1951 and a M.A. in Animal Physiology from Brasenose College at Oxford University in 1953. He was awarded his M.D. from the University of Pennsylvania in 1956 and worked at the National Institutes of Health from 1956-1961 while earning a Ph.D. in Biochemistry from George Washington University. He rose to rank of professor at the School of Medicine at the University of Pennsylvania from 1961-72. He was Chair of Biochemistry at University of Medicine and Dentistry of New Jersey from 1972-1986, Chair of Biochemistry and Director of the Jefferson Institute for Molecular Medicine at Jefferson Medical College from 1986-1996, Director of the Center for Gene Therapy at Hahnemann/Allegheny/Drexel from 1996-2000 and Director of the Center for Gene Therapy at Tulane University Health Science Center from 2000-2008. Dr. Prockop has authored or co‐authored more than 500 publications, is a frequent speaker at distinguished international events pertaining to matrix biology and stem cell science, and has been awarded three honorary degrees. Amongst his many accomplishments are appointments to both the National Academy of Sciences and the National Institute of Medicine. Dr. Prockop joined the faculty at Texas A&M Health Science Center in August 2008.
Currently we are studying the adult stem/progenitor cells from bone marrow referred to as mesenchymal stem cells, multipotent stromal cells or MSCs. The cells have the remarkable ability to home to injured tissues and repair them by a variety of mechanisms that include differentiation, immune modulation, suppression of inflammation, stimulation of tissue-endogenous stem/progenitor cells, and perhaps transfer of mitochondria. The laboratory is engaged in defining the cells with a variety of techniques that include immunocytochemistry, microarrays of transcripts, and proteomics. The cells are being studied in a variety of models for human disease that include heart disease, lung diseases, diabetes, stroke, and head trauma. In addition, plans are being developed to use the cells in clinical trials in patients.
Gregory, C. A., Prockop, D. J., and Spees, J. L. (2005) "Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation." Experimental Cell Research. 306: 330-335.
Gunn, W.G., Conley, A., Deininger, L., Olson, S.D., Prockop, D. J., and Gregory, C.A. (2005) "A Crosstalk between Myeloma Cells and Marrow Stromal Cells Stimulates Production of DKK1 and IL-6: A Potential Role in the Development of Lytic Bone Disease and Tumor Progression in Multiple Myeloma." Stem Cells. 24: 986-991.
Munoz, J. R., Stoutenger, B.R., Robinson, A.P., Spees, J.L., and Prockop, D.J. (2005) "Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice." Proceedings of the National Academy of Sciences. 102: 18171-18176.
Lee, R.H., Hsu, S. C., Munoz, J., Jung, J.S., Lee, N.R., Pochampally, R., and Prockop, D. J. (2006) "A subset of human rapidly-self renewing marrow cells (MSCs) preferentially engraft in mice." Blood. 107: 2153-2161.
Lee, R.H., Seo, M.J., Reger, R.L., Spees, J.L., Pulin, A.A., Olson S.D., and Prockop, D.J. (2006) "Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and perhaps renal glomeruli in diabetic NOD/scid mice." Proceedings of the National Academy of Sciences USA. 103: 17438-17443.
Iso, Y., Spees, J.L., Serrano, C., Bakondi B., Pochampally R., Song, Y.-H., Sobel B.E., Delafontaine, P., and Prockop, D.J. (2007) "Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment". Biochemical and Biophysical Research Communications. 354: 700-706.
Prockop, D. J. (2007) "Stemness” does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs)." Clinical Pharmacology and Therapeutics. 82: 241-243..
Ohtaki, H., Ylostalo, J., Foraker, J. E., Robinson, A. P., Reger R. L., Shioda S., and Prockop, D.J. (2008) "Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory immune responses." Proceedings of the National Academy of Sciences USA. .105(38): 14638-14643.
Oskowitz, A.Z., Lu, J., Penfornis, P., Ylostalo, J., McBride, J., Flemington, E.K., Prockop, D.J., and Pochampally, R. (2008) "Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression." Proceeding of the National Academy of Sciences USA. 105(47): 18372-18377.
Weiss, D.J., Kolls, J.K., Ortiz, L.A., Panoskaltsis-Mortari, A., and Prockop, D.J. (2008) "Stem cells and cell therapies in lung biology and lung diseases." Proceedings of the American Thoracic Society. 5(5): 637-667.
Ylöstalo, J., Bazhanov, N., and Prockop, D.J. (2008) "Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies." Experimental Hematology. 36(10): 1390-1402.
Spees, J.L., Whitney, M.J., Sullivan, D.E., Lasky, J.A., Laboy, M., Ylostalo, J., and Prockop, D.J. (2008) "Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension." FASEB Journal. 22(4): 1226-1236.
Lee, R. H., Seo M. J., Pulin A. A., Gregory C. A., Ylostalo, J. , and Prockop, D. J. (2009) "The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infracted heart in mice." Blood. 113(4):816-826.
Block, G.J., Ohkouchi, S., Fung, F., Frenkel, J., Gregory, C., Pochampally, R., Dimattia, G., Sullivan, D.E., and Prockop, D.J. (2009) "Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1". Stem Cells. 27(3): 670-681.
Prockop, D.J. (2009) "Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing Paradigms." Molecular Therapy. 2009 Mar 31. [Epub ahead of print].