Ashok K. Shetty received his MS degree in human anatomy from Kasturba Medical College of Mysore University in 1983. He obtained his Ph.D. degree in neuroscience from the All India Institute of Medical Sciences, New Delhi in 1990. Following his postdoctoral research work at Montana State University and Duke University, Dr. Shetty joined the Division of Neurosurgery (Department of Surgery) at Duke University Medical Center as an Assistant Professor in 1995. He became an Associate Professor in 1999 and held the position of Professor from 2004 to 2011. Dr. Shetty joined the faculty at Texas A&M University Health Science Center in July 2011.
Dr. Shetty’s current research is funded by grants from the Department of Defense (DOD) and the Department of Veterans Affairs (DVA). Dr. Shetty has authored 107 peer-reviewed publications and his work has appeared in a number of top journals includingMolecular Psychiatry, Neuropsychopharmacology, Journal of Neuroscience, Stem Cells, Aging Cell, Progress in Neurobiology, Neurotherapeutics, Pharmacology and Therapeutics, Neurobiology of Aging, Neurobiology of Disease, Neuroscience and Biobehavioral Reviews, Experimental Neurology and Scientific Reports.
Presently, Dr. Shetty is a charter member of the NIH Study Section, Developmental Brain Disorders (Brain Disorders and Clinical Neuroscience IRG). Previously, Dr. Shetty served as a Charter Member of the National Institutes of Health Study Section CNNT (Brain Disorders and Clinical Neuroscience ZRG1, 2004-2008) and a member of over 25 other study sections of National Institutes of Health, Congressionally Directed Medical Research Program of DOD, Maryland State Stem Cell Research Fund, New York State Stem Cell Research Fund. He has also served as reviewer of grant applications for over 12 international funding agencies from Germany, France, England, Israel, India and Singapore. Dr. Shetty also serves as an Editorial Board Member of many international journals, which includeStem Cells, Aging Cell, Stem Cells International, Current Aging Science, Frontiers in Neurogenesis, Frontiers in Aging Neuroscience, and Stem Cells and Cloning. He is also Co-Editor-in-Chief of the journal,Aging and Disease and Associate Editor of journals, Neurogenesis, Frontiers in Epilepsy, and Molecular and Cellular Epilepsy. Dr. Shetty has received over 5,300 citations for his published research articles. As per the latest Essential Science Indicators of Thompson Reuters, Dr. Shetty is among the top 1% of scientists worldwide in the field of Neuroscience and Behavior, in terms of citations received for published articles over 10 year period.
Dr. Shetty’s laboratory is interested in developing clinically applicable strategies that are efficacious for enhancing brain function after injury, disease or aging. The central areas of investigation include the following: (1) Elucidating mechanisms by which transplanted immature neuronal precursors and neural stem cells (NSCs) and/or GABA-ergic precursor cells derived from embryonic, postnatal and adult brain tissues or human induced pluripotent stem cells (hiPSCs) promote brain repair and ease spontaneous recurrent seizures and cognitive dysfunction in prototypes of status epilepticus, chronic temporal lobe epilepsy (TLE) and traumatic brain injury. (2) Studying mechanisms of brain dysfunction in prototypes of Gulf War Illness and developing treatment strategies to ease cognitive and mood impairments in Gulf War Illness. (3) Developing clinically feasible strategies for improving hippocampus neurogenesis, and memory and mood function in aging and neurological diseases via stimulation of endogenous neural stem/progenitor cells. (4) Analyzing promising neuroprotective compounds and drugs for their usefulness to block chronic epilepsy development after an initial precipitating injury such as status epilepticus or traumatic brain injury (TBI) including mild TBI induced by blast shock waves.