Assistant Professor
Research Scientist II
Digestive Disease Research Center (DDRC)

1901 S 1st Street, Building 205, Room 1R58
Temple, TX 76504
Phone: 254.743.0274
Fax: 254.743.0555

Education and Post-Graduate Training

  • MD, Second Military Medical University, Shanghai, China,1985
  • PhD, Trauma and Burn Institute,  Second Military Medical University, Shanghai, China, 1992
  • MS, Software Engineering, University of Texas at Dallas, Richardson, Texas, 2003

Professional Background

  • Texas A&M University College of Medicine / Instructor, 2005-2006.
  • Texas A&M University College of Medicine / Assistant Professor (Non-Tenure Track), 2006-2007.
  • Ohio State University Medical Center / Assistant Professor (Tenure Track), 2007-2009.
  • Digestive Disease Research Center, Department of Internal Medicine, Scott & White Hospital, Texas A&M HSC College of Medicine / Assistant Professor (PI), 2009-present

Research Interests

  • Functional Role of microRNA and other Non-coding RNAs during Liver Injury (Alcoholic & Non-alcoholic) and Transformation
  • Stem/Progenitor Cells in Liver Injury and Neoplasm
  • Cell and Gene Therapy of Liver Injury and Neoplasm
  • Microarray Bioinformatics in Liver Diseases

Selected Publications

Meng F, Francis H, Glaser S, Han Y, Demorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G.  Role of stem cell factor and granulocyte-colony stimulating factor in remodeling during liver regeneration.  Hepatology. 2011 Sep 19. doi: 10.1002/hep.24673. [Epub ahead of print].  PMID: 21932404

Meng F, Glaser SS, Francis H, Demorrow S, Han Y, Passarini JD, Stokes A, Cleary JP, Liu X, Venter J, Kumar P, Priester S, Hubble L, Stoloch D, Sharma J, Liu CG, Alpini G.  Functional Analysis of microRNAs in Human Hepatocellular Cancer Stem Cells.  J Cell Mol Med. 2011 Feb 25. doi: 10.1111/j.1582-4934.2011.01282.x. [Epub ahead of print].  PMID:  2135247

Meng F, Han Y, Staloch D, Francis T, Stokes A, Francis H.  The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis.  Hepatology. 2011 Nov;54(5):1718-28.

Alpini G, Glaser SS, Zhang JP, Francis H, Han Y, Gong J, Stokes A, Francis T, Hughart N, Hubble L, Zhuang SM, Meng F.  Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.  J Hepatol. 2011 Dec;55(6):1339-45.

Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T. Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene. 2008 Jan 10;27(3):378-86.

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulated expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007 Aug;133(2):647-58.

Meng F*, Henson R, Patel T. Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells.  Am J Physiol Cell Physiol. 2007 Aug;293(2):C749-60.

Meng F, Henson R, Wehbe H, Patel T.  The microRNA let 7A modulates Interleukin-6 dependent Stat-3 survival signaling in malignant human cholangiocytes.  J Biol Chem.  2007 Mar 16;282(11):8256-64.

Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T.Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.  Gastroenterology. 2006 Jun;130(7):2113-29.

Meng F, Yamagiwa Y, Ueno Y, Patel T.   Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes.  J Hepatol. 2006 Jun;44(6):1055-65.

Meng F, Yamagiwa Y, Taffetani S, Han J, Patel T.   IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.  Am J Physiol Cell Physiol. 2005 Oct;289(4):C971-81.