The human microbiota is inextricably linked to health and disease. These trillions of bacteria, viruses and fungi contribute millions of additional genes and metabolites to a host’s own genetic and biochemical repertoire. Healthy microbiota is an essential partner that benefits overall host physiology, metabolism, development and immune homeostasis. Not surprisingly, perturbation of microbiota abundance or diversity (dysbiosis) accompanies many human diseases such as obesity, inflammatory bowel disease, dibetes, cancer, neurological disorders and many others. The growing toolkit to manipulate the human microbiome presents an attractive and underexplored avenue for new therapeutic development and personalized medicine.

The goal of the Core for Integrated Microbiota Research (CIMR) is to facilitate new and innovative research that empowers investigators to remain highly competitive for extramural federal and foundation grants. To this end, the CIMR integrates facilities and expertise of three core components — gnotobiotics, metabolomics and metagenomics — to provide users a seamless, comprehensive workflow for the complete analysis of the microbiota.

Supporters

The CIMR is supported by and administratively headquartered in the Department of Microbial Pathogenesis and Immunology. CIMR is a core resource of and received support from the Center for Translational and Environmental Health Research. The CIMR also received generous, multi-year seed-investments from the College of Medicine, TAMHSC Vice President for Research, and the Texas A&M College of Veterinary Medicine.

Research Impact

To help visualize the far reaching impact of microbiota across numerous fields of research, we've mined PubMed for microbiota disease terms. The following chart displays the number of papers containing microbiota disease terms in PubMed organized by topic.