Lydia Bogomolnaya, PhD
Research Assistant Professor
8447 Riverside Pkwy
Medical Research & Education Building, Room. 3104
Bryan, TX 77807-3260
Lab: 979.436.0363 Fax: 979.436.0360
Education and Post-Graduate Training
BS, Kazan State University, Kazan, Russia, 1997
PhD, Kazan State University, Kazan, Russia, 2001
Post-doctoral training, Texas A&M University, 2001-2005
I am interested in identification of genes that are important for motility of Salmonella. Because motility and virulence are linked and important for Salmonella pathogenesis, we have screened a unique collection of targeted deletion mutants and determined the motility phenotypes on swimming and swarming agar for over 1000 individual deletion mutants. In addition to mutants in genes previously described as important for motility (such as flgF, motA, cheY) we have identified mutants in number of additional genes that are altered in at least one type of movement. As part of this work we also identified a group of mutants that are hypermotile, and have determined that flagella are expressed by some of these mutants at inappropriate times. As flagellins are pathogen associated molecular patterns (or PAMPs), expression of these at inappropriate times during infection may have a drastic effect on pathogenesis.
- Reynolds M.M., Bogomolnaya L.M., Guo J., Aldrich L., Bokhari D., Santiviago C.A., McClelland M., and H.L. Andrews-Polymenis (2011). "Abrogation of the Twin Arginine Transport System in Salmonella enterica serovar Typhimurium Leads to Colonization Defects During Infection." PlosOne (in press).
- Katribe E., Bogomolnaya L.M., Wingert H., Andrews-Polymenis H. "Subspecies IIIa and IIIb Salmonellae are defective for colonization of murine models of salmonellosis compared to Salmonella enterica subsp. I serovar typhimurium" (2009). J Bacteriol. 191(8):2843-50.
- Sivula C.P., Bogomolnaya L.M., Andrews-Polymenis H.L. "A comparison of cecal colonization of Salmonella enterica serotype Typhimurium in white leghorn chicks and Salmonella-resistant mice." (2008) BMC Microbiol. 8:182.
- Bogomolnaya L.M., Santiviago C.A., Yang H.J., Baumler A.J., Andrews-Polymenis H.L. "Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestine." (2008) Mol Microbiol. 70(5):1105-19.
- Blank H.M., Li C., Mueller J.E., Bogomolnaya L.M., Bryk M. and Polymenis M. "An increase in mitochondrial DNA promotes nuclear DNA replication in yeast" (2008). PLoS Genet. 4(4):e1000047. Erratum in: PLoS Genet. 2008 May;4(5). doi: 10.1371/annotation/89355dbd-390e-463f-b804-c6cf1296402e.
- Bogomolnaya L.M., Pathak R., Guo J., Polymenis M. "Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae." (2006) Curr.Genet. 49(6):384-92.
- Pathak R., Bogomolnaya L.M., Guo J., Polymenis M. "A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae" (2005). Curr.Genet. 48(5):300-9.
- Han B.K., Bogomolnaya L.M., Totten J.M., Blank H.M., Dangott L.J., Polymenis M. "Bem1p, a scaffold signaling protein, mediates cyclin-dependent control of vacuolar homeostasis in Saccharomyces cerevisiae" (2005). Genes Dev. 19(21):2606-18.
- Pathak R., Bogomolnaya L.M., Guo J., Polymenis M. "Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae." (2004). Eukaryot. Cell 3(6): 1627-1638
- Bogomolnaya L.M., Pathak R., Guo J., Cham R., Aramayo R., Polymenis M "Hym1p affects cell cycle progression in Saccharomyces cerevisiae" (2004) Curr.Genet 46(4): 183-192.
- Bogomolnaya L.M., Pathak R., Cham R., Guo J., Surovtseva Y.V., Jaeckel L, Polymenis M. "A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae" (2004). Curr.Genet 45(6): 350-359.