Scott V. Dindot, PhD
Education and Post-Graduate Training
Dr. Scott V. Dindot is an assistant professor in the Department of Veterinary Pathobiology. Dindot earned his Bachelor of Science in molecular and cell biology from Texas A&M University in 1999. He received a PhD in genetics from Texas A&M in 2003 in the laboratory of Dr. Jorge Piedrahita. Before joining the Texas A&M faculty in 2008 he was a postdoctoral fellow in the laboratory of Dr. Arthur Beaudet at Baylor College of Medicine in the Department of Molecular and Human Genetics from 2002-2008. His research focused on epigenetics and genomic imprinting. He became a joint faculty member in the Department of Molecular & Cellular Medicine in 2011.
Epigenetic and Genetic Mechanisms of Phenotypic Variation and Disease
My laboratory in interested in understanding the molecular, genetic and epigenetic mechanisms underlying phenotypic variation and disease. We use multifaceted genetic, molecular and cell biological tools as well as genetically engineered model organisms and domestic animal models to understand the interplay between genetics, epigenetics and gene regulation. We further investigate how each modulates phenotypes in some situations and causes disease in others. There are two major areas of research interest in our laboratory. First, we are investigating the epigenetic mechanisms regulating genomic imprinting, including diseases and phenotypes associated with imprinted genes. Second, we are investigating genomic structural variants and their role in phenotypic variation and disease.
- Dindot, Scott V., Piccolo, P., Grove, N., Palmer, D., and Brunetti-Pierri, N. (2010) Intrathecal injection of HdAd vectors results in long-term transgene expression in neuroepyndemal cells and neurons. Human Gene Therapy. Epub Dec.22, 2010.
- Dindot*, S. V., Person, R., Strivens, M., Garcia, R., and Beaudet, R. L. (2009) Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions. Genome Research. 19(8):1374-1383. Epub 2009 Jun 19. *Corresponding author.
- Dindot, S.V., Antalffy, B.A., Bhattacharjee, M.B., and Beaudet, A.L. (2007) The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics. 17(1):111-118. Epub 2007 Oct16
- Dindot, S.V., Kent, K.C., Evers, B., Romano, J., Hansen, G., Luskotoff, N., Womack, J., and Piedrahita, J.A. (2004) Conservation of genomic imprinting at the XJST, IGF2, and GTL2 loci in the bovine. Mammalian Genome. 15(12), 966-974.
- Piedrahita, J., Mir, B., Dindot, S., and Walker, S. (2004). Somatic cell cloning: the ultimate form of nuclear reprogramming. J Am Soc Nephrol. 15(5):1l40-1144.
- Dindot, Scott V., Farm, P., Fan, C., Walker, S., Long, C., and Piedrahita, J.A. (2004) Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. Biology of Reproduction 71(2):470-478.
- Archer*, G.S., Dindot*, S.V., Friend, T.H., Walker, S., Zaunbrecher, G., Lawhorn, B., and Piedrahita, J.A. (2003) Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine. Biology of Reproduction 69, 430-436. *Contributing first author