Cédric G. Geoffroy, PhD
Department of Neuroscience &
8447 Riverside Pkwy
4100 Medical Research and Education Building
Bryan, TX 77807
Education and Post-Graduate Training
Engineer in Biotechnology, Polytech Marseille, France.
PhD, Brain Repair Centre, University of Cambridge, UK.
Postdoctoral Fellow, Department of Neurosciences, UC San Diego, California.
Assistant Project Scientist, Department of Neurosciences, UC San Diego, California.
The main focus of the laboratory is to better understand the molecular, cellular and physiological changes occurring after neurotrauma, in particular after spinal cord injury (SCI). Indeed, SCI is the second cause of paralysis, following close behind stroke. But besides the direct locomotor impairments, SCI also lead to numerous health complications, including metabolic syndrome, respiratory and cardiovascular problems. These health complications not only threaten patients’ lives, but also impact their quality of life. Therefore, one major aim in my lab is to better understand the physiopathology of the SCI and health complications occurring after chronic SCI (in mouse models of SCI). Using genetic and pharmacological approaches, we aim at finding targets that can reduce incidence of these health issues as well as reverse them in more chronic models.
The second goal of my lab is to understand how age impacts SCI. Indeed, SCI increasingly afflicts the middle-aged population, as a result of both later average incidence (from ~29 in the 1970s to ~42 since 2010) and aging of SCI-paralyzed patients (~75% of people with SCI are over 40 years old). Recently, we demonstrated that axon regeneration is impaired after injury in older animals. This decline in axon growth can be controlled by both neuronal intrinsic and extrinsic factors. By better understanding the players involved in this age-dependent growth decline, we aim at finding targets to promote axon growth after SCI and ultimately promote locomotor function recovery in the middle-aged population.
Molecular biology (PCR, plasmid construction, virus…); biochemistry (western blotting…); genetics (RNA-sequencing, gene-editing, transgenic animals); cell culture (primary cell culture of neurons, astrocytes, macrophages); live cell imaging; flow cytometry; immunocyto- and histochemistry, fluorescent microscopy; small animal surgeries (spinal cord injury models, intraspinal and intracranial microinjections), non-invasive measurements (cardiovascular functions analysis, ultrasound imaging…), locomotor function analysis, drug testing.
- Geoffroy CG#, Meves JM, Zheng B#. The age factor in axonal repair after spinal cord injury: a focus on neuron-intrinsic mechanisms. Neurosci Lett. 2016 Nov 3. pii: S0304-3940(16)30842-4. #co-corresponding authors.
- Geoffroy CG*, Hilton BJ*, Tetzlaff W#, Zheng B#. Evidence for an age-dependent decline in axon regeneration in the adult mammalian central nervous system. Cell Rep. 2016 Apr 12;15(2):238-46. *Co-first authors; #co-corresponding authors. PMCID: PMC5050004.
- Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep. 2016 Aug 11;6:31482. PMCID: PMC4980599.
- Geoffroy CG, Lorenzana AO, Kwan JP, Lin K, Ghassemi O, Ma A, Xu N, Creger D, Liu K, He Z, Zheng B. Effects of PTEN and Nogo co-deletion on corticospinal axon sprouting and regeneration in mice. J Neurosci. 2015 April, 35(16):6413-28. PMCID: PMC4405557.
- Geoffroy CG and Zheng B. Myelin-Associated Inhibitors in axon growth after CNS injury. Curr Opin Neurobiol. 2014 Mar 6;27C:31-38. PMCID: PMC4122599.
- Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 2010 Jun 10;66(5):663-70. PMCID: PMC2896331.
- Geoffroy CG, Critchley JA, Castro DS, Ramelli S, Barraclough C, Descombes P, Guillemot F, Raineteau O. Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues. Stem Cells. 2009 Apr;27(4):847-56.
- Geoffroy CG, Raineteau O. A Cre-lox approach for transient transgene expression in neural precursor cells and long-term tracking of their progeny in vitro and in vivo. BMC Dev Biol. 2007 May 15;7:45. PMCID: PMC1885435.