Raimund Ober, PhD
Education and Post-Graduate Training
Dr. Raimund Ober received his undergraduate degree in 1982 at the University of Tubingen, Germany with studies in mathematics and physics.
In 1984 he received a Masters in Mathematics at Cambridge University and his PhD in engineering in 1987.
Dr. Raimund J. Ober is a professor in the Department of Biomedical Engineering and the Department of Molecular & Cellular Medicine at Texas A&M University. His research interests relate to the development and application of engineering principles to problems in molecular/cellular biology, cancer therapeutics and immunology.
Of particular interest is the development of new microscopy techniques and, more specifically, single molecule microscopy approaches. His theoretical and experimental investigations of the classical resolution problem showed that there is no resolution limit in a microscope, but that distances well below those estimated by Rayleigh's criterion can be resolved.
He has pioneered the development of a new microscopy modality, multifocal plane microscopy, to enable the study of fast cellular transport processes in three dimensions. Using microscopy and other techniques, his research group and collaborators investigate the dynamics and transport of new therapeutics and their interactions with their target proteins in a cellular context; for example, engineered antibodies that target tumor cells. The main areas of application are cancer biology and immunology, autoimmunity, etc. They also have studied the molecular basis for the transport of therapeutic agents to specific subcellular compartment and related questions in pharmacokinetics.
- Ober, R. J., Tahmasbi, A., Lin, Z., Ward, E. S. (2015) Quantitative Aspects of Single-Molecule Microscopy: Information-theoretic analysis of single-molecule data. IEEE Signal Processing Magazine, 32(1): 58-69. http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6975295
- Tahmasbi, A., Ram, S., Chao, J., Abraham, A. V., Tang, F. W., Ward, E. S., and Ober, R.J. (2014) Designing the focal plane spacing for multifocal plane microscopy, Opt. Express. 22(14):16706-21. doi: 10.1364/OE.22.016706. PMID: 25090489. http://www.ncbi.nlm.nih.gov/pubmed/25090489
- Ram, S., Ober, R.J. and Ward, E.S.. (2014) E The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells. mAbs. 6(5):1211-1219. doi: 10.4161/mabs.29865. PMID: 25517306. http://www.ncbi.nlm.nih.gov/pubmed/25517306
- Swiercz, R., Chiguru, S., Tahmasbi, A., Ramezani, S. M., Hao, G., Challa, D. K., Lewis, M. A., Kulkarni, P. V., Sun, X, Ober, R. J., Mason, R. P., and Ward, E. S. (2014) Use of Fc-engineered antibodies as clearing agents to increase contrast during PET, J. Nucl. Med., 55(7):1204-1207. PMID: 24868106.http://www.ncbi.nlm.nih.gov/pubmed/24868106
- Poovassery, J.S., Kang, J.C., Kim, D., Ober, R.J., and Ward, E.S. (2014) Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer, Int J Cancer. doi: 10.1002/ijc.29378. [Epub ahead of print] PMID: 25471734 . http://www.ncbi.nlm.nih.gov/pubmed/25471734
- Kang, J.C., Poovassery, J.S., Bansal, P., You, S., Manjarres, I.M., Ober R.J., and Ward E.S. (2014) Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells. mAbs, 6(2): 340-353. http://www.ncbi.nlm.nih.gov/pubmed/24492289
- Wong, Y., Chao, J., Lin, Z., and Ober, R.J. (2014) Effect of time discretization of the imaging process on the accuracy of trajectory estimation in fluorescence microscopy. Opt Express. 22(17):20396-20420. doi: 10.1364/OE.22.020396. PMID: 25321248 http://www.ncbi.nlm.nih.gov/pubmed/25321248
- Challa, D.K., Velmurugan, R., Ober, R.J., Ward, E.S. (2014) FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions. Curr Top Microbiol Immunol. 382:249-272. doi: 10.1007/978-3-319-07911-0_12. Review. PMID: 25116104 http://www.ncbi.nlm.nih.gov/pubmed/25116104
- Ward, E.S., Velmurugan, R., and Ober, R.J. (2014) Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice. Immunol Lett. 160(2):158-62. doi: 10.1016/j.imlet.2014.02.008. Epub 2014 Feb 23. PMID: 24572175 http://www.ncbi.nlm.nih.gov/pubmed/24572175
- Devanaboyina, S.C., Lynch, S.M., Ober, R.J., Ram, S., Kim, D., Puig-Canto, A., Breen, S., Kasturirangan, S., Fowler, S., Peng, L., Zhong, H., Jermutus, L., Wu, H., Webster, C., Ward, E.S., and Gao, C. (2013) The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics. mAbs. 5(6):851-859. doi: 10.4161/mabs.26389. PMID: 24492341 http://www.ncbi.nlm.nih.gov/pubmed/24492341
- Cohen, E.A.K., and Ober, R.J. (2013) Analysis of Point Based Image Registration Errors with Applications in Single Molecule Microscopy. IEEE Transactions on Signal Processing, 61(24):6291-6306. http://www.ncbi.nlm.nih.gov/pubmed/24634573
- Challa, D.K., Bussmeyer, U., Khan, T., Perez Montoyo, H., Bansal, P., Ober, R.J. and Ward E.S. (2013) Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis, mAbs, 5:655-659. http://www.ncbi.nlm.nih.gov/pubmed/23846320
- Bansal, P., Khan, T., Bussmeyer, U., Challa, D., Swiercz, R., Ober, R.J. and Ward E.S. (2013) The encephalitogenic, human myelin oligodendrocyte glycoprotein-induced antibody repertoire is directed towards multiple epitopes in C57BL/6-immunized mice, Journal of Immunology, 191, 1091-1101.http://www.ncbi.nlm.nih.gov/pubmed/23817425
- Chao, J., Ram, S., Ward E.S., and Ober, R.J. (2013) Ultrahigh accuracy imaging modality for super- localization microscopy, Nature Methods, 10: 335-338. http://www.ncbi.nlm.nih.gov/pubmed/23455923
- Gan, Z., Ram, S., Ober, R.J. and Ward E.S. (2013) Using multifocal plane microscopy to reveal novel intracellular trafficking processes on the recycling pathway. Journal of Cell Science, 126: 1176-1188. http://www.ncbi.nlm.nih.gov/pubmed/23345403