Van G. Wilson, PhD
Education and Post-Graduate Training
BS Georgia Institute of Technology (1975)
PhD Case Western Reserve University (1980)
Postdoc. State University of New York (1980-83)
My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein. In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation. We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.
- Deyrieux, A.F. and V.G. Wilson. 2017. Sumoylation in Development and Differentiation. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series
Advances in Experimental Medicine and Biology pp 197-214.
Deyrieux, A.F. and V.G. Wilson. 2017. Viral Interplay with the Host Sumoylation System. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series Advances in Experimental Medicine and Biology pp 359-388.
Wilson, V.G. 2017. Introduction to Sumoylation. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series Advances in Experimental Medicine and Biology pp 1-12.
Wilson, V.G. 2014. The Role of Ubiquitin and Ubiquitin-Like Modification Systems in Papillomavirus Biology. Viruses. 2014; 6(9):3584-3611. PMC4189040
Wilson, V.G. 2012. SUMOylation at the Host-Pathogen Interface. Biomolecules 2, 203-227, 2012. PMCID: PMC3685863
- Wilson, V.G. 2013. Growth and Differentiation of HaCaT Keratinocytes. In Epidermal Cells: Methods and Protocols (Methods in Molecular Biology series). Humana Press. Ed. K. Turksen. In Press.
- Heaton, P.R. Rosas-Acosta, G., and Wilson, V.G., 2012. Analysis of global sumoylation changes during keratinocyte differentiation. PLoS ONE 7(1): e30165. doi:10.1371/journal.pone.0030165. PMCID: PMC3264615
- Tidwell, J.A., Schmidt, C., Heaton, P.R., Wilson, V.G., and P.W. Tucker. 2011. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID31-mediated immunoglobulin gene transcription. Molecular Immunology 49:260-272. PMCID:PMC3205283
- Heaton, P.R., Deyrieux, A.F., Bian, X-L., and Wilson, V.G., 2011. HPV E6 Proteins Target Ubc9, the SUMO Conjugating Enzyme. Virus Research 158:199-208. PMCID: PMC3103646.
- Bian, X.-L. and Wilson, V.G., 2010. Common Importin Alpha Specificity for Papillomavirus E2 Proteins. Virus Research doi:10.1016/j.virusres.2010.02.011. PMID: 20193720
- Nanos-Webb, A., Deyrieux, A., Bian, X.-L., Rosas-Acosta, G. and Wilson, V.G., 2010. Cloning the Human SUMO1 Promoter. Molecular Biology Reports 37:1155-1163.. PMID: 19242820
- Wu, Y.-C., Bian, X.-L., Heaton, P.R., and V.G. Wilson, V.G., 2009. Host Sumoylation Level Influences Papillomavirus E2 Protein Stability. Virology 387:176-183. Chosen by Faculty of 1000. PMID: 19251296
- Schmidt, C., Kim, D., Ippolito, G.C., Naqvi, H.R., Probst, L., Mathur, S., Rosas-Acosta, G., Wilson, V.G., Oldham, A.L., Poenie, M., Webb, C.F., and P.W. Tucker. 2009. Signaling of the BCR is regulated by a lipid rafts-localized transcription factor, Bright. EMBO J. 28:711-724. PMID: 19214191