Ashok K. Shetty

Ashok K. Shetty

Professor, Department of Molecular and Cellular Medicine

Associate Director, Institute for Regenerative MedicineResearch Career Scientist, Olin E. Teague Veterans’ Affairs Medical Center, Central Texas Veterans Healthcare System


240A Reynolds Medical Building
College Station, TX   77843-1114

Phone: 979-436-9653
Fax: 979-847-9481
shetty@medicine.tamhsc.edu

Education and Post-Graduate Training

Ashok K. Shetty received his MS degree in human anatomy from Kasturba Medical College of Mysore University in 1983. He obtained his Ph.D. degree in neuroscience from the All India Institute of Medical Sciences, New Delhi in 1990. Following his postdoctoral research work at Montana State University and Duke University, Dr. Shetty joined the Division of Neurosurgery (Department of Surgery) at Duke University Medical Center as an Assistant Professor in 1995. He became an Associate Professor in 1999 and held the position of Professor from 2004 to 2011. Dr. Shetty joined the faculty at Texas A&M University Health Science Center in July 2011.

Dr. Shetty has received continuous extramural research funding as Principal Investigator for over 20 years from sources such as the National Institutes of Health (NIH), Department of Defense (DoD) and Department of Veterans Affairs (DVA). His current research is funded by grants from the DoD and DVA. Dr. Shetty has so far authored 121 peer-reviewed publications and his work has appeared in many top class journals including Molecular Psychiatry, Proceedings of the National Academy of Sciences (PNAS, USA), Neuropsychopharmacology, Journal of Neuroscience, Stem Cells, Aging Cell, Progress in Neurobiology, Neuroscience and Biobehavioral Reviews, Pharmacology and Therapeutics, Neurobiology of Aging, Neurobiology of Disease, Experimental Neurology, Neurotherapeutics, Stem Cells Translational Medicine and Nature Scientific Reports. Dr. Shetty has received over 6,700 citations (with an h-index of 45) for his published research articles.

Dr. Shetty has the distinction of serving on two different NIH Study Sections as Chartered Member. These include Clinical Neuroplasticity and Neurotransmitters study section panel (Brain Disorders and Clinical Neuroscience ZRG1) from 2004-2008, and Developmental Brain Disorders study section panel (Brain Disorders and Clinical Neuroscience IRG) from 2010-2016. In addition, he has served as an ad-hoc member of over 30 other study section panels of NIH, Congressionally Directed Medical Research Program of DoD, Maryland State Stem Cell Research Fund, New York State Stem Cell Research Fund and Henry M. Jackson Foundation Regenerative Medicine Program of NIH and DoD. He has also served as reviewer of grant applications for over 12 international funding agencies from Germany, France, England, Israel, India and Singapore. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging and Disease, and Associate Editor of journals, Neurogenesis, Frontiers in Epilepsy, and Molecular and Cellular Epilepsy. Dr. Shetty also serves as an Editorial Board Member of many international journals, which include Stem Cells, Aging Cell, Stem Cells International, Frontiers in Neurogenesis, Frontiers in Aging Neuroscience, Frontiers in Pharmacology, and Cell Transplantation.

Research Interests

Dr. Shetty’s laboratory is interested in developing clinically applicable strategies that are efficacious for enhancing brain function after injury, disease or aging. The central areas of investigation include the following: (1) Elucidating mechanisms by which transplanted immature neuronal precursors and neural stem cells (NSCs) and/or GABA-ergic precursor cells derived from embryonic, postnatal and adult brain tissues or human induced pluripotent stem cells (hiPSCs) promote brain repair and ease spontaneous recurrent seizures and cognitive dysfunction in prototypes of status epilepticus, chronic temporal lobe epilepsy (TLE) and traumatic brain injury. (2) Studying mechanisms of brain dysfunction in prototypes of Gulf War Illness and developing treatment strategies to ease cognitive and mood impairments in Gulf War Illness. (3) Developing clinically feasible strategies for improving hippocampus neurogenesis, and memory and mood function in aging and neurological diseases via stimulation of endogenous neural stem/progenitor cells. (4) Analyzing promising neuroprotective compounds and drugs for their usefulness to block chronic epilepsy development after an initial precipitating injury such as status epilepticus or traumatic brain injury (TBI) including mild TBI induced by blast shock waves.

Resources

Original Research Articles

  • Kodali M, Megahed T, Mishra V, Shuai B, Hattiangady B, Shetty AK (2016): Voluntary running exercise mediated enhanced neurogenesis does not obliterate retrograde spatial memory. Journal of Neuroscience. 36:8112-8122. https://www.ncbi.nlm.nih.gov/pubmed/27488632
  • Shetty AK, Hattiangady B (2016): Grafted subventricular zone neural stem cells display robust engraftment and similar differentiation properties and form new neurogenic niches in the young and aged hippocampus. Stem Cells Translational Medicine. 5:1204-15. https://www.ncbi.nlm.nih.gov/pubmed/27194744
  • Kim DK, Nishida H, An SY,Shetty AK, Bartosh TJ, Prockop DJ (2016). Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proceedings of the National Academy of Sciences, USA. 113: 170-175. http://www.pnas.org/content/113/1/170.long
  • Kodali M, Parihar VK, Hattiangady B, Mishra V, Shuai B, Shetty AK (2015): Resveratrol prevents age-related memory and mood function with increased hippocampal neurogenesis and microvasculature, and reduced glial activation. Scientific Reports, 5:8075. http://www.nature.com/srep/2015/150128/srep08075/full/srep08075.html
  • Mishra V, Shuai B, Kodali M, Shetty GA, Hattiangady B, Rao X, Shetty AK (2015): Resveratrol treatment after status epilepticus restrains neurodegeneration and abnormal neurogenesis with suppression of oxidative stress and inflammation. Scientific Reports (Nature Publishing Group), 5:17807; Dec 7. http://www.nature.com/articles/srep17807
  • Megahed T, Hattiangady B, Shuai B, Shetty AK (2015) Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf war illness. Frontiers in Cellular Neuroscience, 8:447. http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00447/full
  • Hattiangady B, Mishra V, Kodali M, Shuai B, Rao, X, Shetty AK (2014): Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness. Frontiers in Behavioral Neuroscience, 8:78, eCollection. http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00078/full
  • Parihar VK, Hattiangady B, Shuai B, Shetty AK (2013): Mood and memory deficits in a model of Gulf war illness are linked with reduced neurogenesis, partial neuron loss and mild inflammation in the hippocampus. Neuropsychopharmacology, 38: 2348-2362. http://www.nature.com/npp/journal/v38/n12/full/npp2013158a.html
  • Shetty GA, Hattiangady B, Shetty AK (2013): Neural stem cell- and neurogenesis-related gene expression profiles in the young and aged dentate gyrus. AGE, 35: 2165-2176. http://www.ncbi.nlm.nih.gov/pubmed/23322452
  • Watanabe J, Shetty AK, Hattiangady B, Kim DK, Foraker JE, Nishida H, Prockop DJ (2013) Administration of TSG-6 improves memory after traumatic brain injury in mice. Neurobiology of Disease, 59:86-99. http://www.ncbi.nlm.nih.gov/pubmed/23851308
  • Hattiangady B, Shetty AK (2012): Neural stem cell grafting counteracts hippocampal injury-mediated impairments in mood, memory and neurogenesis. Stem Cells Translational Medicine, 1:696-708. http://stemcellstm.alphamedpress.org/content/1/9/696.long
  • Parihar VK, Hattiangady B, Kuruba R, Shuai B, Shetty AK (2011): Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory. Molecular Psychiatry, 16, 171-183. http://www.ncbi.nlm.nih.gov/pubmed/20010892
  • Waldau B, Hattiangady B, Kuruba R, Shetty AK (2010): Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy. Stem Cells, 28, 1153-1164. http://onlinelibrary.wiley.com/doi/10.1002/stem.446/full
  • Hattiangady B, Shetty AK (2010) Decreased neuronal differentiation of newly generated cells underlies diminished neurogenesis in chronic temporal lobe epilepsy. Hippocampus, 20:97-112. http://www.ncbi.nlm.nih.gov/pubmed/19309040
  • Hattiangady B, Rao MS, Shetty AK (2008): Grafting of Striatal Precursor Cells into Hippocampus Shortly after Status Epilepticus Restrains Chronic Temporal Lobe Epilepsy. Experimental Neurology. 212:468-481. http://www.ncbi.nlm.nih.gov/pubmed/18579133
  • Hattiangady B, Rao MS, Shetty AK (2008): Plasticity of hippocampal stem/progenitor cells to enhance neurogenesis in response to injury is lost by middle age, Aging Cell, 7:207-224. http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2007.00363.x/full
  • Hattiangady B, Shetty AK (2008): Aging Does not Alter the Number or Phenotype of Putative Stem/Progenitor Cells in the Neurogenic Region of the Hippocampus. Neurobiology of Aging, 29:129-147. http://www.ncbi.nlm.nih.gov/pubmed/17092610
  • Hattiangady B, Shuai B, Cai J, Coksaygan T, Rao MS,Shetty AK (2007): Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus. Stem Cells, 25:2104-2117. http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2006-0726/full
  • Rao MS, Hattiangady B, Shetty AK (2006): The window and mechanisms of major age related decline in the production of new neurons within the dentate gyrus of the hippocampus. Aging Cell, 5:545-558. http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2006.00243.x/full
  • Shetty AK, Hattiangady B, Shetty GA (2005): Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes, Glia, 51:173-186. http://www.ncbi.nlm.nih.gov/pubmed/15800930
  • Shetty AK, Zaman V, Hattiangady B (2005): Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy. Journal of Neuroscience, 25: 8391-8401. http://www.jneurosci.org/content/25/37/8391.long

Review Articles