James E. Womack

James E. Womack

Joint Professor, W.P. Luse Endowed and Distinguished Professor

Department of Molecular and Cellular Medicine
Room 309, VMR Building
College Station, TX   77843

Phone: 979.845.9810
Fax: 979.845.9972

Education and Post-Graduate Training

Dr. James E. Womack is a Distinguished Professor in the Department of Veterinary Pathobiology at Texas A&M University and has a joint appointment in the Department of Molecular and Cellular Medicine at the Texas A&M College of Medicine. Womack earned his Bachelor of Science in mathematics education from Abilene Christian College in 1964. He received a PhD in genetics from Oregon State University in 1968.

Womack then joined the Department of Biology at Abilene Christian College as an assistant professor and was promoted to associate professor in 1971. He joined the Jackson Laboratory as a visiting scientist in 1973 and became a staff scientist in 1975 before joining the Texas A&M University faculty in 1977 as an associate professor. His research focused on comparative genome organization in mammals. He was promoted to professor in 1981 and two years later received the W. P. Luse Endowed Professorship. From 1989 to 1996 he was director of the Center for Animal Genetics at the Institute of Biosciences & Technology. He was named interim associate department head for the Department of Veterinary Pathobiology from 1990 to 1993. Womack has been a member of National Academy of Sciences since 1999 and received the Wolf Prize in Agriculture in 2001. He became a joint faculty member in the Department of Molecular and Cellular Medicine at the Texas A&M College of Medicine in 1991.

Research Interests

My research interests are comparative genomics with emphasis on evolutionary relationships of mammalian genomes. I have specifically targeted the bovine genome and its relationship to the genomes of humans and mice with a variety of techniques including somatic cell genetics, linkage mapping, radiation hybrid mapping and physical mapping, including large scale sequencing. The application of this information has been focused on animal health including the search for genes controlling host resistance or susceptibility to infectious diseases, particularly zoonotic and emerging diseases. These studies are important for the development of animal models of both human and animal health.

Selected Publications

Murphy, W.J,. Larkin, D.M., Everts-van der Wind, A., Borque, G., Tesler, G., Auvil, L., Beever, J.E., Chowdhary, B.P., Galibert, F., Gatzke, L., Hitte, C., Meyers, S.N., Milan, D., Ostrander, E.A., Pape, G., Parker, G.H., Raudseep, T, Rogatcheva, M.B., Schook, L.B., Skow, L.C., Welge, M., Womack, J.E., O’Brien, S.J., Pevzner, P.A., and Lewin, H.A. (2005): Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science. 309: 613-617.

Everts-van der Wind, A., Larkin, D.M., Green, C.A., Elliott, J.S., Olmstead, C., Chiu, R., Schein, J.E., Marra, MA, Womack, J.E., Lewin, H.A. (2005): A high-resolution whole-genome cattle-human comparative map reveals details of mammalian chromosome evolution. Proc. Natl. Acad. Sci. USA. 102:18526-18531.

Sugimoto, M., Fujikawa, A., Womack, J.E., and Sugimoto, Y. (2006). Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proc. Natl. Acad. Sci. USA. 103:6454-6459.

Taylor, K.H., Taylor, J.F., White, S.N., and Womack, J.E.: (2006). Identification of genetic variation and putative regulatory regions in bovine CARD15. Mammalian Genome. 17:892-901.

Cargill, E.J. and Womack, J.E.: (2007) Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9. Genomics. 89:745-755.

Seabury, C.M., Cargill, E.J., and Womack, J.E.: (2007). Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5 and 10. Genomics. 90:502-515.

Bovine Genome Sequencing and Analysis Consortium: 315 authors including Womack, J.E.: (2009) The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science. 324:522-528.

Bovine HapMap Consortium. 90 authors including Womack, J.E.: (2009). Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science. 324:528-532.

Goldammer, T., Brunner, R.M., Rebl, A., Wu, C.H., Nomura, K., Hadfield, T., Gill, C., Dalrymple, B.P., Womack, J.E., and Cockett, N.E.: (2009). A high-resolution radiation hybrid map of sheep chromosome X and comparison with human and cattle. Cytogenetics and Genome Res. 125:40-45.

Gillenwaters, E.N., Seabury, C.M., Elliott, J.S., and Womack, J.E.: (2009) Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family. J.Hered. 100:241-245.