E. Sally Ward, Ph.D.

E. Sally Ward, Ph.D.


Department of Molecular and Cellular Medicine and Department of Microbial Pathogenesis and Immunology
Reynolds Medical Building
Room 469
College Station, TX   77807

Phone: 979-436-0742
Fax: 979-847-9481

Education and Post-Graduate Training

Sally Ward received her B.A. with First Class Honours in Natural Sciences (Part II course, Biochemistry), University of Cambridge, U.K., in 1982 and completed her Ph.D. in Biochemistry at the Department of Biochemistry, University of Cambridge, under the mentorship of Professor David J. Ellar in 1985. From 1988-1990 she held the Stanley Elmore Senior Medical Research Fellow at Sidney Sussex College, Cambridge whilst working with Sir Greg Winter at the MRC Laboratory of Molecular Biology, Cambridge, U.K. She became an Assistant Professor in 1990 at the University of Texas Southwestern Medical Center in Dallas.  Dr. Ward was promoted in 2002 to Professor in the Department of Immunology at UT Southwestern and was appointed to the Paul and Betty Meek-FINA Professorship in Molecular Immunology in 2004.  Dr. Ward joined the faculty at Texas A&M Health Science Center in September 2014.

Research Interests

The Ward laboratory is run jointly with the laboratory of Dr. Raimund Ober. The research is directed towards taking a highly interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mouse models of disease. These studies are funded by the National Institutes of Health, National Multiple Sclerosis Society, Cancer Prevention and Research Institute of Texas (CPRIT) and biopharma.


  • Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y., and Ward, E. S. (1996) Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice, Eur. J. Immunol., 26, 690-696. PMID: 8605939 http://www.ncbi.nlm.nih.gov/pubmed/8605939
  • Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J., and Ward, E. S. (1997) Increasing the serum persistence of an IgG fragment by random mutagenesis, Nat. Biotechnol., 15, 637-640. PMID: 9219265 http://www.ncbi.nlm.nih.gov/pubmed/9219265
  • Garcia, K. C., Radu, C. G., Ho, J., Ober, R. J., and Ward, E. S. (2001) Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis, Proc. Natl. Acad. Sci. USA, 98, 6818-6823. PMID:11391002 http://www.ncbi.nlm.nih.gov/pubmed/11391002
  • Ober, R. J., Martinez, C., Lai, X., Zhou, J., and Ward, E. S. (2004) Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level, Proc. Natl. Acad. Sci. USA, 101, 11076-11081. PMID: 15258288 http://www.ncbi.nlm.nih.gov/pubmed/15258288
  • Ober, R. J., Martinez, C., Vaccaro, C., Zhou, J., and Ward, E. S. (2004) Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn, J. Immunol., 172, 2021-2029. PMID: 14764666 http://www.ncbi.nlm.nih.gov/pubmed/14764666
  • Vaccaro, C., Zhou, J., Ober, R. J., and Ward, E. S. (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels, Nat. Biotechnol., 23, 1283-1288. PMID: 16186811 http://www.ncbi.nlm.nih.gov/pubmed/16186811
  • Vaccaro, C., Bawdon, R., Wanjie, S., Ober, R. J., and Ward, E. S. (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies, Proc. Natl. Acad. Sci. USA, 103, 18709-18714. PMID: 17116867 http://www.ncbi.nlm.nih.gov/pubmed/17116867
  • Prabhat, P., Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R. J., and Ward, E. S. (2007) Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, using multifocal plane microscopy, Proc. Natl. Acad. Sci. USA, 104, 5889-5894. PMID: 17384151http://www.ncbi.nlm.nih.gov/pubmed17384151
  • Perez-Montoyo, H., Vaccaro, C., Hafner, M., Ober, R. J., Mueller, W., and Ward, E. S. (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice, Proc. Natl. Acad. Sci. USA, 106, 2788-2793. PMID: 19188594 http://www.ncbi.nlm.nih.gov/pubmed/19188594
  • Patel., D.A., Puig Canto, A., Challa, D.K., Perez Montoyo, H., Ober, R.J. and Ward, E.S. (2011) Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model, J. Immunol., 187, 1015-1022. PMID: 21690327 http://www.ncbi.nlm.nih.gov/pubmed/21690327
  • Gan, Z., Ram, S., Ober, R.J. and Ward, E.S. (2013) Using multifocal plane microscopy to reveal novel trafficking processes on the recycling pathway, J. Cell Sci., 126, 1176-1188. PMID: 23345403 http://www.ncbi.nlm.nih.gov/pubmed/23345403
  • Chao, J., Ram, S., Ward, E.S. and Ober, R.J. (2013) Ultrahigh accuracy imaging modality for super-localization microscopy, Nat. Methods, 10, 335-338. PMID: 23455923 http://www.ncbi.nlm.nih.gov/pubmed/23455923
  • Bansal, P., Khan, T., Bussmeyer, U., Challa, D.K., Swiercz, R., Velmurugan, R., Ober, R.J. and Ward, E.S. (2013) The encephalitogenic, human myelin oligodendrocyte glycoprotein-induced antibody repertoire is directed toward multiple epitopes in C57BL/6 mice, J. Immunol., 191, 1091- 1101. PMID: 23817425 http://www.ncbi.nlm.nih.gov/pubmed/23817425
  • Poovassery, J. S., Kang J. C., Kim, D., Ober, R. J., Ward, E. S. (2014) Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer, Int. J. Cancer, 2014 Dec 4. doi: 10.1002/ijc.29378. [Epub ahead of print] PMID: 25471734 http://www.ncbi.nlm.nih.gov/pubmed/25471734
  • Swiercz, R., Chiguru, S., Tahmasbi, A., Ramezani, S. M., Hao, G., Challa, D. K., Lewis, M. A., Kulkarni, P. V., Sun, X., Ober, R. J., Mason, R. P., and Ward, E. S. (2014) Use of Fc-engineered antibodies as clearing agents to increase contrast during PET, J.Nucl. Med., 55, 1204-1207. PMID: 24868106 http://www.ncbi.nlm.nih.gov/pubmed/24868106