Van G. Wilson, PhD

Van G. Wilson, PhD

Professor and Associate Dean for Research and Graduate Studies


Department of Microbial Pathogenesis and Immunology
8447 Riverside Pkwy
Medical Research & Education Building (MREB), Rm. 1001
Bryan, TX   77807-3260

Phone: 979.436.0310
Fax: 979.436.0086
wilson@medicine.tamhsc.edu

Education and Post-Graduate Training

BS Georgia Institute of Technology (1975)

PhD Case Western Reserve University (1980)

Postdoc. State University of New York (1980-83)

Research Interests

My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein.   In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation.  We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.

Selected Publications

Deyrieux, A.F. and V.G. Wilson. 2017. Sumoylation in Development and Differentiation. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series Advances in Experimental Medicine and Biology pp 197-214.

Deyrieux, A.F. and V.G. Wilson. 2017. Viral Interplay with the Host Sumoylation System. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series Advances in Experimental Medicine and Biology pp 359-388.

Wilson, V.G. 2017. Introduction to Sumoylation. In SUMO Regulation of Cellular Processes. Springer Press, Ed. V.G. Wilson. 2017. Volume 963 of the series Advances in Experimental Medicine and Biology pp 1-12.

Wilson, V.G. 2014. The Role of Ubiquitin and Ubiquitin-Like Modification Systems in Papillomavirus Biology. Viruses. 2014; 6(9):3584-3611. PMC4189040

Wilson, V.G. 2012. SUMOylation at the Host-Pathogen Interface. Biomolecules 2, 203-227, 2012. PMCID: PMC3685863

Wilson, V.G. 2013. Growth and Differentiation of HaCaT Keratinocytes. In Epidermal Cells: Methods and Protocols (Methods in Molecular Biology series). Humana Press. Ed. K. Turksen. In Press.

Heaton, P.R. Rosas-Acosta, G., and Wilson, V.G., 2012. Analysis of global sumoylation changes during keratinocyte differentiation.  PLoS ONE 7(1): e30165. doi:10.1371/journal.pone.0030165. PMCID: PMC3264615

Tidwell, J.A., Schmidt, C., Heaton, P.R., Wilson, V.G., and P.W. Tucker. 2011. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID31-mediated immunoglobulin gene transcription.  Molecular Immunology 49:260-272. PMCID:PMC3205283

Heaton, P.R., Deyrieux, A.F., Bian, X-L., and Wilson, V.G., 2011. HPV E6 Proteins Target Ubc9, the SUMO Conjugating Enzyme. Virus Research 158:199-208. PMCID: PMC3103646.

Bian, X.-L. and Wilson, V.G.,  2010. Common Importin Alpha Specificity for Papillomavirus E2 Proteins.  Virus Research doi:10.1016/j.virusres.2010.02.011. PMID: 20193720

Nanos-Webb, A., Deyrieux, A., Bian, X.-L., Rosas-Acosta, G. and Wilson, V.G.,  2010.  Cloning the Human SUMO1 Promoter.  Molecular Biology Reports 37:1155-1163.. PMID: 19242820

Wu, Y.-C., Bian, X.-L., Heaton, P.R., and V.G. Wilson, V.G.,  2009.  Host Sumoylation Level Influences Papillomavirus E2 Protein Stability.  Virology 387:176-183.  Chosen by Faculty of 1000. PMID: 19251296

Schmidt, C., Kim, D., Ippolito, G.C., Naqvi, H.R., Probst, L., Mathur, S., Rosas-Acosta, G., Wilson, V.G., Oldham, A.L., Poenie, M., Webb, C.F., and P.W. Tucker.  2009.  Signaling of the BCR is regulated by a lipid rafts-localized transcription factor, Bright.  EMBO J. 28:711-724. PMID: 19214191