Neuroscience-Track

The faculty of the Department of Neuroscience and Experimental Therapeutics (NExT) provide instruction in medical and graduate courses.

Medical

  • MEID 905 STRUCTURE AND FUNCTION OF HUMAN ORGAN SYSTEMS. Histology and physiology of the human body presented in an integrated fashion; includes laboratory and application of basic knowledge by introducing various disease conditions.
  • NEXT 901 GROSS ANATOMY. Relationships of structures of the human body during its development and in adult form as revealed through dissection; functional significance.
  • NEXT 922 MEDICAL NEUROSCIENCE is a course that deals with the structure of the human central nervous system (CNS) and relates this structure to function. To help the student obtain a broad understanding of how the CNS functions, this course takes an integrated approach that involves anatomy, physiology, pharmacology, pathology and clinical correlation/problem solving. The student will obtain a three dimensional, functional understanding of both the internal and external anatomy of the CNS. This understanding forms the foundation to fully comprehend, localize and diagnose the underlying causes for a variety of neurologic disorders.
  • NEXT 923 MEDICAL PHARMACOLOGY. General concepts of pharmacological agents and substances; pharmacokinetics; pharmacodynamics; antimicrobial and antineoplastic agents; autonomic drugs; and toxicology. Endocrine pharmacology, renal pharmacology, cardiovascular pharmacology,respiratory pharmacology, neuropharmacology.
  • MPAT 923 GENERAL PATHOLOGY. General characteristics and mechanisms of human disease, including language of disease, basic causes and mechanisms of disease, anatomic and physiologic changes in disease and resulting clinical manifestations.
  • NEXT 981 SEMINAR. Selected topics of current interest are presented. Presentation and defenses of a scientific paper.
  • FIRST YEAR MEDICAL NEUROSCIENCE BLOCK (MEID 936) is the last block of Phase I and runs 9 weeks.  It is unique because it focuses on one organ system (brain, spinal cord & peripheral nerves) from two clinical perspectives (e.g., neurological, brain-nerve disorders and psychiatric, mental-mind disorders).  Neuroscience introduces basic macroscopic anatomical features of the human central nervous system (CNS) using neuroradiographic images, intact and sectioned human brain material and digital images of counterstained sections throughout the neuraxis.  The anatomy of basic functions such as mediation of pain, sensation, motor control, coordination, consciousness, cognition and emotion are mapped onto a three dimensional (3D) CNS structure.  Fundamental knowledge of normal anatomy and function is strengthened by recognizing what functions are lost in classic injuries (e.g., stroke, trauma, neurodegeneration).  The clinical logic and systematic procedures used to identify, localize and evaluate significant lesions in patients with disorders such as peripheral neuropathy, spinal cord or head injury, stroke, epilepsy, meningitis, Parkinson's or Alzheimer's diseases among others are taught.  Brain pathology caused by diverse mechanisms such as microbial agents, toxins, trauma, congenital defects, metabolic, immune, circulatory or neurodegenerative processes and tumors are defined and neurological consequences characterized.  The concept of mental health is addressed, including the hallmark characteristics of prominent mental illnesses such as depression, schizophrenia, dementia, psychosis, post-traumatic stress, anxiety, personality, mood, self-image, violence, substance abuse and suicide are explained.  CNS and autonomic nervous system active drugs are introduced in close association with the prominent clinical disorders for which they are prescribed to integrate current knowledge of mechanisms of action, dose-response and prominent side effects with primary indications such as epilepsy, Parkinson's, depression, alcohol abuse or clinical interventions like anesthesia and pain management.  Successful completion of the Neuroscience block provides an integrated basic knowledge of the vulnerability of the brain/spinal cord to injury and disease, the resulting dysfunctional consequences and the array of pharmacotherapies currently available to clinicians to help patients.  Knowledge of these core principles is essential for successful experiences in 2nd year preceptorships, USMLE Step 1 exam, 3rd/4th year clerkships and future medical practice!

Graduate

  • NEXT 985 PROBLEMS. Research in specialized areas of neuroscience, anatomy, and pharmacology.
  • NEXT 989 SPECIAL TOPICS IN... Selected topic in an advanced area of medical neuroscience, anatomy, and medical pharmacology.
  • 991 RESEARCH. Individual research projects conducted under the direction of a supervising professor. Prerequisite: Approval of department head.
  • MSCI 601  Molecular basis of cellular functions in human body: technologies forprobing cellular functions and structures; plasma membranes and intracellular organelles; gene function; cell metabolism; cell motility and cytoskeleton
  • NEXT 603 NEUROPSYCHOPHARMACOLOGY. Interaction of drugs and toxins with neurotransmitter systems with primary emphasis on mechanisms involving receptor function that impacts central nervous system integration.
  • NEXT 605 Molecular Mechanisms of Drug and Toxin Actions I  Introduction to the major tools and concepts of pharmacology. This is a two part series (see MPHM 606). By the end of these courses, the student will understand how selectivity of drug action is determined by pharmacological principles and will have a scientific basis for a rational approach to the study of drug actions and side effects.
  • NEXT 606 Molecular Mechanisms of Drug and Toxin Actions II -  Survey of ocular drugs, overview of molecular signaling mechanisms and selected topics in developmental neuropharmacology.
  • NEXT 607 MOLECULAR MECHANISMS OF DRUG AND TOXIN ACTION III. Interaction of drugs and toxins with neurotransmitter systems with primary emphasis on mechanisms involving receptor function that impacts central nervous system integration.
  • NEXT 609 INTRACELLULAR SIGNALING. Introduction to signaling pathways inside cells that mediate multi-step cascades following cell surface receptor activation and how these pathways are influenced by drugs.
  • NEXT 610 ORGAN-SPECIFIC TOXICOLOGY. Introduction to critical mechanisms of toxic injury of organ systems with emphasis on liver, kidney, lung, central nervous system and reproductive tract and overview of classic toxicants.
  • MSCI 612 CURRENT TOPICS IN CELL SIGNALING. The course provides an overview of intracellular signal transduction pathways utilized by various classes of growth factor, cytokine, integrin and G protein coupled receptors. The course also will provide a clear understanding of the importance of these pathways in regulating cell growth, differentiation, apoptosis and other cellular processes, both under normal physiologic conditions as well as diseases.
  • NEXT 621 TEACHING GROSS ANATOMY. Provides teaching and supervisory experience for graduate students; instructs students in teaching and supervising medical students in Gross Anatomy (MANA 901); student(s) observe in the laboratory and present at least one lecture.
  • NEXT 622 TEACHING MEDICAL HISTOLOGY. Provides teaching and supervisory experience for graduate students; instructs students in teaching and supervising medical students in Microscopic Anatomy (MANA 911); student(s) observe in the laboratory and present at least one lecture.
  • NEXT 623 TEACHING IN MEDICAL NEUROSCIENCE. Assist in the teaching of Medical Neuroscience (MANA 922), to include lecture(s), laboratories and examination setup and proctoring.
  • NEXT 681 SEMINAR. Focus will be on critical scientific thinking. Emphasis placed on oral communications, scientific writing and grant preparation.
  • NEXT 685 DIRECTED STUDIES. Limited investigation in fields other than those chosen for thesis or dissertation.
  • NEXT 685-629 BIOLOGY OF NON-CODING RNA'S. For more information contact Dr. Rajesh Miranda.
  • NEXT 689 SPECIAL TOPICS IN ... Selected topics in an identified area of pharmacology and toxicology.
  • NEXT 689-631 NEUROSCIENCE JOURNAL CLUB. 1CR. Discussion of current Neuroscience literature. Students are expected to attend and participate in all club meetings (weekly; 1hr) and present at least one paper.