George C.Y. Chiou, Ph.D.

George C.Y. Chiou, Ph.D.

Professor for Department of Neuroscience and Experimental Therapeutics, Professor and Director for Institute of Ocular Pharmacology, Founding Editor, Journal of Ocular Pharmacology and Therapeutics


Phone: 979-845-2817
Fax: 979-845-0699
chiou@medicine.tamhsc.edu

Education

Ph.D. in Pharmacology, Vanderbilt University

Postdoctoral Research in Autonomic Pharmacology, University of Iowa Medical School

Research Interests

  1. Treatment of uveitis and systemic inflammation with novel interleukin-1 blockers
  2. Systemic delivery of peptide drugs through the eyes
  3. Treatment of open-angle glaucoma and ischemic retinopathy with dopamine antagonists
  4. Action mechanisms of nitric oxide precursors for ischemic stroke and ocular hypertension
  5. Ocular pharmacology of natural products isolated from medicinal plants
  6. Treatment of dry-ARMD (Age related macular degeneration)

Selected Publications

Park, YH, Xu, XR and Chiou, GCY. (2004) "Structure requirements of flavonoids for increment of ocular blood in the rabbit, and retina function recovery in the rat". J. Ocular Pharmacol. Ther. in press.

Chiou, GCY and Xu, XR. (2004) "Effects of some natural flavanoids on retinal function recovery after ischemic insult in the rat". J. Ocular Pharmacol. Ther. in press.

Park, YH and Chiou, GCY. (2004) "Sturcture-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit". Journal of Ocular Pharm. Ther. 20:35-42.

Park, YH, Xu, XR and Chiou, GCY. (2004) "Effects of hydroxy groups in natural flavones on ocular blood flow of rabbits and retinal function recovery after ischemia insult in rat eyes". International Journal of Ophthalmology. 4:1-6.

Xuan, B and Chiou, GCY. (2003) "Release of nitric oxide by N-nitropyrazoles in rabbit lacrimal gland cell cultures". J. Ocular Pharmacol. 19:265-270.

Beauregard, C, Brandt, PC and Chiou, GCY. (2003) "Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1? in cultured lacrimal gland acinar cells". Exp. Eye Res. 77:109-114.

Xuan, B, Wang, T, Chiou, GCY, Dalinger, IL, Shkineva, TK and Shevlov, SA. (2002) "Effects of c-nitropyrazoles and c-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult". Acta Pharmacol. Sinica. 23:705-712.

Xuan, B, Wang, T, Chiou, GCY, Dalinger, I, Shkineva, TK and Shevelev, SA. (2001) "Effects of N-nitropyrazoles on ocular blood flow in rabbit eyes and retinal function recovery after ischemic insult in rat eyes". J. Ocular Pharmacol. 17:505-515.

Wang, T, Xuan, B, Chiou, GCY, Dalinger, I, Shkineva, TK, and Shevelev, SA. (2001) "Effects of N-nitropyrazoles on ocular blood flow of rabbits and retinal function recovery of rat eyes after ischemic insults". J. Ocular Pharmacol. 17:505-515.

Beauregard, C, Brandt, PC, Chiou, GCY and Xuan, B. (2001) "Over-expression of nitric oxide by pro-inflammatory cytokines in cultured lacrimal gland cells: a possible factor in dry eye syndrome. Association for Research in Vision and Ophthalmology Annual Meeting". Invest. Ophthal. Vis. Sci. 42:S258.

Beauregard, C, Liu, Q, and Chiou, GCY. (2001) "Effects of nitric oxide donors and nitric oxide synthase substrates on ciliary muscle contracted by carbachol and endothelin for possible use in myopia prevention". J. Ocular Pharmacol. 17:1-10.

Chiou, GCY. (2001) "Review: Effects of nitric oxide on eye diseases and their treatment". J. Ocular Pharmacol. 17:189-198.

Chiou, GCY, Xuan, B, Liu, Q, Yamasaki, T, and Okawara, T. (2001) "Inhibition of IL-1-induced uveitis and corneal fIbroblast proliferation by some synthetic IL-1 blockers". J. Ocular Pharmacol. 16:407-418.

Varma, RS, Xuan, B and Chiou, GCY. (2000) "Effects of nitric oxide donors on the retinal function measured with electroretinography". J. Ocular Pharmacol. 16:571-578.

Chiou-Tan, FY and Chiou, GCY. (2000) "Contribution of circulating acetlycholine to sensory nerve conduction augmentation". Life Sci. 66:1509-1518.