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Anatoliy Gashev, M.D., Ph.D., D.MSci.

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Anatoliy Gashev, M.D., Ph.D., D.MSci.

Associate Professor
Systems Biology and Translational Medicine

702 Southwest H.K. Dodgen Loop
Temple, Texas 76504
Phone: 254-742-7174
Fax: 254-742-7145
Email: gashev@tamu.edu
Curriculum Vitae (PDF)

Education and Post-Graduate Training

M.D., Therapy, General Practice, State Medical Academy, St. Petersburg, Russia, 1986

Ph.D., Physiology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia, 1989

Doctor of Medical Science, Physiology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia, 2000

Research Interests

Dr. Anatoliy Gashev, M.D., Ph.D., D.Med.Sci. has been involved in studies on physiology of lymph transport and its regulatory mechanisms for over 30 years beginning with training during his M.D. and Ph.D. programs in St. Petersburg, Russia. His expertise includes different aspects of hydrodynamics and functional characterizations of the contractile patterns of lymphatic networks from multiple anatomical regions and species both in vitro and in vivo as well as the molecular regulation of stretch- and shear-dependent adaptive reactions of contracting lymphatic vessels. Currently, a major focus of Dr. Gashev's research relates to the mechanisms of age-related alterations in lymphatic pumping and in interactions between lymph vessels and surrounding tissue microenvironment for which he is currently supported by a NIH NIA R01 grant. Dr. Gashev's expertise has gained him worldwide recognition as represented by his role as reviewer for numerous journals and invitations to speak at numerous national and international conferences relating to cardiovascular and lymphatic biology and therapeutics.

Selected Publications

Gashev AA. [The pump function of the lymphangion and the effect on it of different hydrostatic conditions]. [Article in Russian]. Fiziol Zh SSSR Im I M Sechenova. 1989 Dec;75(12):1737-1743. PMID: 2628032  

Gashev AA, Orlov RS, Zawieja DC. [Contractions of the lymphangion under low filling conditions and the absence of stretching stimuli. The possibility of the sucking effect]. [Article in Russian]. Ross Fiziol Zh Im I M Sechenova. 2001 Jan; 87(1):97-109. PMID: 11227869  

Gashev AA, Davis MJ, Zawieja DC. Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct. J Physiol. 2002 May 1;540(Pt 3):1023-1037. PMID: 11986387; PMCID: PMC22908276  

Gashev AA, Davis MJ, Delp MD, Zawieja DC. Regional variations of contractile activity in isolated rat lymphatics. Microcirculation. 2004 Sep;11(6):477-492. PMID: 15371129  

Gasheva OY, Zawieja DC, Gashev AA. Contraction-initiated NO-dependent lymphatic relaxation: a self-regulatory mechanism in rat thoracic duct. J Physiol. 2006 Sep 15;575(Pt 3):821-32. PMID: 16809357; PMCID: PMC1995691  

Gasheva OY, Knippa K, Nepiushchikh ZV, Muthuchamy M, Gashev AA. Age-related alterations of active pumping mechanisms in rat thoracic duct. Microcirculation. 2007 Nov-Dec;14(8):827-839. PMID: 17924280  

Gashev AA. Lymphatic vessels: pressure- and flow-dependent regulatory reactions. Ann N Y Acad Sci. 2008;1131:100-109. PMID: 18519963  

Gashev AA, Davis MJ, Gasheva OY, Nepiushchikh ZV, Wang W, Dougherty P, Kelly KA, Cai S, von der Weid PY, Muthuchamy M, Meininger CJ, Zawieja DC. Methods for lymphatic vessel culture and gene transfection. Microcirculation. 2009 Oct;16(7):615-628. PMID: 19626551; PMCID: PMC3042427  

Nagai T, Bridenbaugh EA, Gashev AA. Aging-associated alterations in contractility of rat mesenteric lymphatic vessels. Microcirculation. 2011 Aug;18(6):463-473. doi: 10.1111/j.1549-8719.2011.00107.x. PMID: 21466607; PMCID: PMC3148320 [Available on 2012/8/1]  

Akl TJ, Nagai T, Coté GL, Gashev AA. Mesenteric lymph flow in adult and aged rats. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1828-1840. PMID: 21873496. PMCID: PMC3213968 [Available on 2012/11/11]