Pediatrics

Larry Herrera, M.D.

Childhood leukemia/cell surface signaling in leukemia

Development and testing of novel monoclonal antibodies and antibody-conjugates for the treatment of childhood leukemia and lymphoma.

Induction of apoptosis using combinations of antibodies and chemotherapy

Investigation in the signaling potential of monoclonal antibodies directed against cell surface antigens on leukemia cells to enhance the effect of chemotherapy. This work is supported by a Career Scientist Development Award from the NIH

Herrera L, Yarbrough S, Ghetie V, Aquino D.B., Vitetta E: Treatment of SCID/Human B-Cell Precursor ALL with Anti-CD19 and Anti-CD22 Immunotoxins. Leukemia 17:334-338, 2003.

Herrera, C.S., Herrera,L., Morgan,C., Alfano R., Sukamar, S., Ghetie,V., Vitetta E: Anti-CD19 Immunotoxin Enhances Anti-Leukemia Activity of Chemotherapy in SCID/Human Pre-B Acute Lymphoblastic Leukemia. Submitted to Leukemia. 2005